Evidence map›Paper›PMID 40986267›Full record

ArticleClinical rheumatology2025

Association between tooth loss and clinical complications in rheumatoid arthritis: a pilot study.

Laura Silva Siano Rodrigues, Victoria Boëchat Feyo, Lydia Silva Provinciali, José Jonas Pereira, Cristhiane Almeida Leite da Silva, Viviane Angelina de Souza, Cynthia Savioli, Gisele Maria Campos Fabri

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Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura Silva Siano RodriguesSchool of Dentistry, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.ORCID http://orcid.org/0000-0001-9820-3663
Victoria Boëchat FeyoSchool of Dentistry, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.ORCID http://orcid.org/0000-0002-6265-6422
Lydia Silva ProvincialiSchool of Dentistry, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.ORCID http://orcid.org/0000-0001-5423-4150
José Jonas PereiraInstitute of Exact Sciences, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.ORCID http://orcid.org/0000-0001-9243-6888
Cristhiane Almeida Leite da SilvaSchool of Dentistry, Universidade de Cuiabá, Cuiabá, Brazil.ORCID http://orcid.org/0000-0002-9316-0382
Viviane Angelina de SouzaMedical School, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.ORCID http://orcid.org/0000-0001-6386-3776
Cynthia SavioliCollege of Dentistry, University of Florida, Gainesville, USA.ORCID http://orcid.org/0009-0006-4765-1443
Gisele Maria Campos FabriDepartment of Dental Clinic, School of Dentistry, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil. gisele.fabri@ufjf.br.ORCID http://orcid.org/0000-0002-8396-0722

Funding

National Council for Scientific and Technological Development 117795/2023-2
6 · The paper itself

Abstract

introductionRheumatoid Arthritis (RA) is a chronic autoimmune disease that affects the oral cavity, contributing to the development of periodontal disease (PD), an inflammatory condition that has a bidirectional relationship with various systemic conditions and can lead to tooth loss (TL).This study aimed to evaluate whether the number of missing teeth could serve as an additional indicator for the medical team in assessing the association with systemic disease exacerbations.

methodsThis pilot study assessed patients with rheumatoid arthritis (RA) using specific protocols, including medical record analysis and a systematic orofacial examination to calculate the Decayed, Missing, and Filled Teeth (DMFT) index. Validated questionnaires were applied, and the disease activity (DAS-28) and functional capacity (HAQ) indices were collected.

resultsThe study included 21 patients with a mean DAS28 of 3.12 and a mean HAQ of 1.077. Of these, 7 (33.4%) were in remission, while 14 (66.6%) had some level of disease activity. 10 (47%) had moderate to severe disability due to RA. Statistical analysis identified polypharmacy as a clinically relevant factor associated with tooth loss (p = 0.029; r = 0.48). Additionally, patients with disease activity had higher DMF-T scores. Correspondence analysis indicated that polypharmacy was associated with a higher prevalence of moderate to severe disability (HAQ) and higher DMF-T scores.

conclusionIt is concluded that there is a relationship between the DMF-T index, RA activity, the number of missing teeth, and the need for polypharmacy, making these data important to be assessed in the clinical routine of RA patients. Additional studies are necessary to explore this association in greater depth and strengthen the evidence base.

Indexed as

Arthritis, RheumatoidTooth LossAdultAgedFemaleHumansMaleMiddle AgedPilot ProjectsPolypharmacySeverity of Illness IndexSurveys and QuestionnairesDMF indexPolypharmacyRheumatoid arthritisTooth loss

Identifiers

PMID40986267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.