ArticleAnnals of biomedical engineering2025
Conceptual Design and Additive Manufacturing of a Bidirectional Gradient Gyroid Structure for Tibial Stem.
Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAdvancements in additive manufacturing technology have facilitated the use of cellular lattice structures for orthopedic implants. Gradient porosity can enhance the biomechanical performance of cementless implants by improving fixation and reducing aseptic loosening. Previous studies designing gradient cellular implants have been often limited to unidirectional graded structures. This study aimed at conceptual design of bidirectional graded lattice structures for the tibial stem of total knee replacement (TKR), to enhance osteogenic response and periprosthetic bone remodeling.
methodsA multi-objective optimization problem was addressed using the design of experiment approach to find the optimal gradient parameters. Three finite element models, including a preoperative, an early postoperative, and a late postoperative model of the TKR, were developed to predict the osseointegration and remodeling behaviors, based on a computational mechanobiology framework.
resultsFive optimal graded lattice structures were obtained, each hypothetically appropriate for a specific group of patients. A low porosity (20% density) axially graded structure was predicted to induce a strong osteogenic response, as needed for over-aged patients with weak osteoblast activity. Also, a high porosity (10% density) radially graded structure was predicted to lead to a low bone resorption, as required for young adults demanding long implant lifespan. The overall optimal structure made of bidirectional gradient (27% radial and 73% axial) with high porosity (10% density) was predicted to enhance the bone remodeling with minimal change in osteogenic response. SEM examination of the graded gyroid specimens, fabricated by selective laser melting, revealed small fabrication errors compared to the average lattice dimensions.
conclusionComputational and experimental results were promising and provided supportive evidence for the beneficial impact of bidirectional graded tibial stems and their manufacturability.
Indexed as
Identifiers
40986252What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.