ArticleFish physiology and biochemistry2025
Unravelling the hsp70 gene in snubnose pompano (Trachinotus blochii): insights into stress response mechanisms.
Article in Fish physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Whole-larval innate immune-associated biochemical profiles during early ontogeny of silver pompano (Trachinotus blochii).Fish physiology and biochemistry · 2026Article
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10 authors.
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Abstract
Heat shock proteins (HSPs) are molecular chaperones that play a crucial role in fish physiology from stress-induced damage by stabilizing proteins and enhancing survival under environmental challenges. This study characterizes the stress-responsive hsp70 (tb-ihsp70) gene in Trachinotus blochii, a prime marine aquaculture species, from an evolutionary perspective and links its expression to salinity and pathogen stress. The tb-ihsp70 encodes a 639 amino acid protein with conserved ATPase and substrate-binding domains critical for protein conformation under stress. Phylogenetic analysis grouped it within Carangidae, showing a strong link to Trachinotus ovatus, with marine and freshwater species forming distinct clades, reflecting the environmental role in its phylogeny. Structural modelling revealed a Y-shaped conformation with high-confidence validation scores. STRING analysis identified functional partners, highlighting involvement in broader stress response pathways. The intronless feature and expression profiling classified tb-ihsp70 as a constitutively expressed and moderately inducible HSP70. Expression in healthy fish was maximum in gill > posterior kidney > spleen > liver > heart. Salinity stress showed significant upregulation at 3‰ on day two (7.95-fold) and three (5.26-fold), while no significant changes were observed at 42‰ on any day, indicating a stronger and longer tb-ihsp70 induction at lower salinity levels. Vibrio harveyi challenge peaked expression at 12 h in spleen (73.86-fold), heart (40.88-fold), and posterior kidney (23.10-fold). In conclusion, this first comprehensive characterization underscores the role of tb-ihsp70 in biotic and abiotic stress adaptation, supporting its potential as a molecular biomarker for T. blochii health research in mariculture.
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