ArticleInfectious diseases and therapy2025
Temporal Dynamics of SARS-CoV-2 Detection in Household Contacts: Divergences Between Time to First Positive Test, Symptom Onset, and Maximum Viral Load.
Article in Infectious diseases and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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10 authors.
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Abstract
introductionUnderstanding the temporal dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is crucial for optimizing diagnostic strategies. This prospective cohort study aimed to quantify the temporal viral transmission dynamics and biomarker profiles among households containing a SARS-CoV-2-positive index patient (IP) and uninfected household contacts (HHCs).
methodsIPs entered the study within 48 h after confirmation of SARS-CoV-2 through reverse transcription polymerase chain reaction (RT-PCR). During 10-13 follow-up visits at days 0-7, and every 3-4 days thereafter until day 30 (± 6 days), nasopharyngeal swab and saliva samples were collected from participants (IP and HHC), and quantified via RT-PCR. Viral loads were estimated from cycle threshold values using three independently validated reference curved. Temporal viral dynamics for HHCs were evaluated as median times to first positive test (T
resultsWe prospectively screened 30 households with SARS-CoV-2-negative index cases; nine had a subsequent index-HHC conversion to PCR-positive, and 89 samples were generated. The results revealed a median T
conclusionThese findings suggest that SARS-CoV-2 viral RNA is detectable before symptom onset, and emphasize the need for testing immediately after exposure with repeated testing in the first week. This study provides critical insights into the temporal interplay of viral kinetics, aiding the development of targeted diagnostic and public health interventions. Further research is needed to validate these findings across larger, diverse cohorts and evolving viral variants. Testing immediately after exposure, with repeat testing during the first week may improve case detection.
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