Observational studyJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2026
Older age is not an independent predictor of syncope recurrence following cardioneuroablation for reflex syncope.
Observational study in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Cardioneuroablation for Reflex Syncope and Functional Bradyarrhythmias: A State-of-the-Art Review.Journal of clinical medicine · 2026Review
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Authors and funding
7 authors.
Funding
Abstract
backgroundCardioneuroablation (CNA) is a promising tool to treat reflex syncope; however, optimal age cut-off values to undergo CNA have not been established.
methodsThis is a prospective observational single-center study which included all consecutive patients with cardioinhibitory reflex syncope treated with CNA who completed at least 1 year of follow-up. Bi-atrial CNA was performed using anatomical approach with the use of electro-anatomical mapping system, intracardiac echocardiography and extracardiac vagal stimulation.
resultsThe study group consisted of 209 patients (mean age 39.5 ± 13.6, 121 (58%) females). During a median follow-up of 27 months, 166 (79.4%) patients remained free from syncope recurrence, and syncope burden was significantly reduced (6.67 syncope/year vs. 0.26 syncope/year, p = 0.00001). Univariate analysis showed that hypertension, number of syncopal episodes, and age ≥ 60 years were associated with syncope recurrence; however, age was not an independent variable predicting the outcome. There was no significant difference in the outcome between patients aged < 40 vs. ≥ 40 or < 50 vs. ≥ 50 years. The reduction of syncope burden was significant in younger age groups but not in patients aged ≥ 60 years. During follow-up, six patients received pacemaker-all were >50 years old.
conclusionsAge is not an independent predictor of CNA efficacy; however, patients aged >60 years, particularly those with concomitant hypertension and a high number of syncopal episodes, tend to have higher syncope recurrence and less reduction in syncope burden than younger people. The need for permanent pacing due to ineffective CNA increases with age, starting from 55 years.
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