ArticleOdontology2026
Linking systemic inflammation to periodontal disease: insights from blood-derived biomarkers in NHANES.
Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association between Albumin-to-Globulin Ratio and Periodontitis: A Cross-Sectional and Mendelian Randomisation Analysis.Oral health & preventive dentistry · 2026Article
- m5c-modified LINC01094 participates in epithelial-mesenchymal transition and metastasis of cervical cancer cells via the ZNF582-SIRT1/p53 axis.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Periodontitis is a prevalent inflammatory disease linked to systemic immune activation and associated with various chronic conditions. Blood-derived inflammatory markers, such as the albumin-to-globulin ratio (AGR), may offer insights into systemic inflammation related to periodontitis, yet their role remains underexplored. This study aimed to investigate the association between AGR and other inflammatory markers with periodontitis in a representative U.S. adult population. A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2009 to 2014, including 10,135 adults aged ≥ 30 years with complete periodontal and laboratory data. Periodontitis was defined using CDC/AAP criteria. AGR, systemic immune-inflammatory index, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and platelet-to-lymphocyte ratio were calculated from routine blood parameters. Associations between periodontitis and those inflammatory markers were assessed using multivariable logistic regression adjusted for sociodemographic, lifestyle, metabolic factors, systemic conditions, and liver function markers. Non-linear relationships were explored with restricted cubic splines. AGR was inversely associated with periodontitis in all models (Model 3: OR = 0.62, 95% CI: 0.49-0.78; P < 0.001). A significant L-shaped non-linear relationship was observed, with a threshold at AGR = 1.778. Below this value, each unit increase in AGR was associated with a 54% lower odds of periodontitis (OR = 0.46, 95% CI: 0.34-0.63). No significant non-linear associations were found for albumin, globulin, SII, PLR, or LMR. A significant gender interaction was detected (P < 0.001). Lower AGR was independently associated with greater odds of periodontitis, highlighting the potential role of systemic inflammatory biomarker in the pathophysiology of periodontitis. Longitudinal studies are needed to confirm causality.
Indexed as
Identifiers
40986126What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.