Trial reportEuropean journal of nutrition2025
Effect of probiotics on intestinal permeability in critically ill children with sepsis: preliminary results from a double-blind, placebo-controlled trial.
Trial report in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- The role of probiotics in nutritional intake and clinical outcomes of critically Ill children with severe sepsis: a double-blind, placebo-controlled trial.Scientific reports · 2026Trial
- Integrating gut‑brain axis insights into bundled nutrition care for critically ill patients: From mechanisms to implementation (Review).Molecular medicine reports · 2026Review
- The leaky gut and microbiome in critical illness: emerging insights into microbial "translocation".Current opinion in critical care · 2026Review
- Travel-Induced Circadian and Microbiota Disturbances: Implications for Athlete Health and Performance: A Narrative Review.Nutrients · 2026Review
- The effects of high-protein vs conventional protein enteral nutrition on intestinal permeability, severity of disease, and mortality in critically ill intensive care unit Patients: Protocol for a randomized controlled trial.Contemporary clinical trials communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeThe objective of this study was to evaluate whether probiotics have effects on intestinal permeability in children with sepsis.
methodsSeptic children who were admitted to the pediatric intensive care unit (PICU) were included in this randomized double-blind study. Children received 2*10
resultsAfter 1 week of therapy, the levels of zonulin and LBP were reduced in the probiotic group compared to the placebo group, albeit there were no significant between-group differences for both (P = 0.88 for zonulin, P = 0.53 for LBP). In terms of inflammatory cytokines, probiotic usage led to a significant reduction in IL-6 (- 25.1 ± 29.1 pg/mL, P = 0.001) and an increase in IL-10 levels (25.4 ± 41.6 pg/mL, P < 0.001) with a significant difference between the two groups (P < 0.001). There were no differences between groups for other secondary outcomes, PICU/hospital stay, and mortality. Likewise, no serious side effects were seen after probiotic treatment in the study group.
conclusionTreatment of pediatric septic with probiotics was followed by improvement in inflammatory cytokines. Although we are not able to infer those probiotics provided benefit for intestinal permeability markers and known important clinical outcomes in pediatric sepsis. TRIAL REGISTRY: Registered at the Iranian Registry of Clinical Trials ( www.irct.ir ) with the number IRCT20170202032367N10.
Indexed as
Identifiers
40986080What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.