SynthesisGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Efficacy and safety of subconjunctival or subtenon injection versus soaked sponge mitomycin C in trabeculectomy: a systematic review and meta-analysis.
Synthesis in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
purposeTrabeculectomy is the gold standard for glaucoma management, offering effective intraocular pressure reduction. The method of mitomycin C (MMC) application plays a critical role in surgical success. This study evaluates the impact of different MMC administration techniques on key clinical outcomes to inform surgical decision-making.
methodsA systematic review was conducted by searching EMBASE, Medline, and CENTRAL, yielding 709 records. Dichotomous outcomes, including complete and qualified success, were analyzed using odds ratios (OR) with 95% confidence intervals (CI), while continuous outcomes, such as postoperative intraocular pressure (IOP), were evaluated using mean difference (MD) with 95% CI. Heterogeneity (I
resultsOur systematic review included 11 studies involving a total of 1,153 patients. The meta-analysis revealed that subconjunctival or subtenon injections significantly improve the complete success rates compared to soaked sponges MMC [OR = 1.44, 95% CI = (1.04, 1.99); Number Needed to Treat (NNT) = 12, 95% CI = (7, 104)]. However, no significant differences were observed in qualified success rates between injections and soaked sponges [OR = 0.67; 95% CI = (0.37, 1.22) and OR = 0.82; 95% CI = (0.36, 1.86), respectively]. Regarding postoperative IOP, injection methods also significantly reduced postoperative IOP compared to soaked sponges [MD: -0.69 mmHg; 95% CI = (-1.30, -0.07)].
conclusionMMC injections provide superior complete success rates and better IOP control compared to soaked sponges. Further well-designed RCTs are required to determine their efficacy and safety.
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