Evidence map›Paper›PMID 40985996›Full record

ArticleHematological oncology2025

A SWOT-Consensus for CAR-T in Follicular Lymphoma: Fine Tuning of Patient Journey and Selection.

Monia Marchetti, Paolo Corradini, Luca Arcaini, Stefania Bramanti, Alice Di Rocco, Marco Ladetto, Stefano Luminari, Luigi Rigacci, Pier Luigi Zinzani

Abstract readConsensus Statement
In one paragraph

Article in Hematological oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Monia MarchettiSCDU Ematologia, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Paolo CorradiniDivisione di Ematologia, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Cattedra di Ematologia, Università degli Studi di Milano, Milan, Italy.
Luca ArcainiDivisione di Ematologia, Dipartimento di Medicina Molecolare, Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID https://orcid.org/0000-0002-9504-991X
Stefania BramantiIRCCS Humanitas Research Hospital, Haematology, Milan, Italy.
Alice Di RoccoDipartimento Medicina Traslazionale e di Precisione, Ematologia, Università Sapienza di Roma, Roma, Italy.
Marco LadettoUniversità del Piemonte Orientale, SCDU Ematologia, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Stefano LuminariEmatologia, Azienda USL IRCCS Reggio Emilia, Reggio Emilia, Italy.ORCID https://orcid.org/0000-0001-8446-2285
Luigi RigacciUOC Ematologia Fondazione Policlinico Universitario Campus Bio-Medico e Research Unit of Hematology Department of Medicine and Surgery, Università Campus Bio-Medico Roma, Roma, Italy.
Pier Luigi ZinzaniIRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy.ORCID https://orcid.org/0000-0002-2112-2651

Funding

Novartis
6 · The paper itself

Abstract

Over the past 2 decades, advancements in follicular lymphoma (FL) treatment, particularly with anti-CD20 antibodies, have significantly improved patient survival. However, a subset of FL patients experiences early relapse and progression within 24 months (POD24) after first line treatment, which is a sign of poor prognosis. Current guidelines recommend various second-line treatments, but there is no consensus on an optimal treatment sequence for relapsed/refractory (r/r) FL. Moreover, despite available treatments, reduced survival after second-line therapies and diminishing responses with each relapse highlight the unmet need for more effective options. Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a promising treatment for r/r FL beyond 2

Indexed as

Immunotherapy, AdoptiveLymphoma, FollicularReceptors, Chimeric AntigenConsensusHumansPatient SelectionReceptors, Chimeric AntigenCAR‐T therapyearly patient selectionrelapsed/refractory follicular lymphomathird‐line treatment

Identifiers

PMID40985996
PMCPMC12456390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.