Evidence map›Paper›PMID 40985980›Full record

ArticleACS applied bio materials2025

Amino Silane High Positive Charge Layers: A Stable and Durable Alternative Based on Electrostatic Interactions for Titanium Applications, Combining Antimicrobial and Biological Properties.

João Pedro Dos S Silva, Mariana Mireski, Irene Mallor-Solís, Maria Helena Rossy Borges, Rodolfo Debone Piazza, Rodrigo Fernando Costa Marques, Nilson Cruz, Elidiane C Rangel, Carlos A Fortulan, José H D da Silva and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

João Pedro Dos S SilvaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP). Av. Limeira, 901, Piracicaba, São Paulo 13414-903, Brazil.
Mariana MireskiDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP). Av. Limeira, 901, Piracicaba, São Paulo 13414-903, Brazil.
Irene Mallor-SolísBioinspired Oral Biomaterials and Interfaces─BOBI, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC)-Barcelona Tech, Barcelona 08019, Spain.
Maria Helena Rossy BorgesDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP). Av. Limeira, 901, Piracicaba, São Paulo 13414-903, Brazil.
Rodolfo Debone PiazzaLaboratory of Magnetic Materials and Colloids, Department of Analytical, Physico-Chemistry and Inorganic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP 14800-060, Brazil.
Rodrigo Fernando Costa MarquesLaboratory of Magnetic Materials and Colloids, Department of Analytical, Physico-Chemistry and Inorganic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP 14800-060, Brazil.
Nilson CruzLaboratory of Technological Plasmas, Institute of Science and Technology, São Paulo State University (UNESP), Av. Três de Março, 511, Sorocaba, São Paulo 18087-180, Brazil.ORCID 0000-0002-0354-3890
Elidiane C RangelLaboratory of Technological Plasmas, Institute of Science and Technology, São Paulo State University (UNESP), Av. Três de Março, 511, Sorocaba, São Paulo 18087-180, Brazil.ORCID 0000-0001-7909-190X
Carlos A FortulanDepartment of Mechanical Engineering, University of São Paulo (USP), Trabalhador São Carlense, 400, São Carlos, São Paulo 13566-590, Brazil.
José H D da SilvaDepartment of Physics, School of Sciences, São Paulo State University (UNESP), Av. Eng. Luís Edmundo C. Coube, 14-01, Bauru, São Paulo 17033-360, Brazil.
Jean GeringerMines Saint-Etienne, Université de Lyon, Université Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, Department BioMat, F-42023 Saint-Etienne, France.
Conrado AparicioBioinspired Oral Biomaterials and Interfaces─BOBI, Department of Materials Science and Engineering, Universitat Politècnica de Catalunya (UPC)-Barcelona Tech, Barcelona 08019, Spain.ORCID 0000-0003-2969-6067
Valentim A R BarãoDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP). Av. Limeira, 901, Piracicaba, São Paulo 13414-903, Brazil.ORCID 0000-0002-6391-9917

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cationic coatings on titanium surfaces are a promising approach for dental and biomedical implants due to their low-cost antimicrobial effect and no need for antibiotics. These coatings are applied on hydroxylated (-OH) surfaces using silanes, such as 3-aminopropyltriethoxysilane (APTES). However, it is unclear whether the concentration of this organofunctional compound affects surface charge or potential toxicity. This study investigated how different concentrations of APTES in cationic coatings on titanium samples influence electrostatic behavior and interactions with bacteria and mesenchymal stem cells (MSCs). Titanium discs served as controls (Ti group) and were first treated by plasma electrolytic oxidation (PEO) to generate -OH groups (PEO group). Subsequently, APTES was applied at 83.8, 167.6, and 251.4 mM, forming PEO+APTES0.3, PEO+APTES0.6, and PEO+APTES0.9 groups, respectively. Surfaces were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), contact angle, Zeta potential, and profilometry. Microbiological assays assessed initial bacterial adhesion (1 h) and biofilm formation (24 h) using

Indexed as

Anti-Bacterial AgentsCoated Materials, BiocompatiblePropylaminesSilanesTitaniumAnimalsBacterial AdhesionEscherichia coliHumansMaterials TestingMesenchymal Stem CellsMicrobial Sensitivity TestsParticle SizeStaphylococcus aureusStatic ElectricitySurface Propertiesamino-propyl-triethoxysilaneAnti-Bacterial AgentsCoated Materials, BiocompatiblePropylaminesSilanesTitaniumbiofilmscationic coatingcell proliferationelectrostatic Interactionstitanium

Identifiers

PMID40985980
PMCPMC12541706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.