Evidence map›Paper›PMID 40985893›Full record

ArticleJCI insight2025

Metabolite-enhanced normothermic machine perfusion improves kidney transplant viability.

Jan Czogalla, Fabian Hausmann, Simon Lagies, Sydney E Gies, Sabrina Christiansen, Nico Kaiser, Fabian Haas, Yusuke Okabayashi, Dominik Kylies, Smilla Hofmann and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Jan CzogallaIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Fabian HausmannHamburg Center for Kidney Health (HCKH), Hamburg, Germany.
Simon LagiesCore Competence Metabolomics, Hilde-Mangold-Haus, and.
Sydney E GiesIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sabrina ChristiansenIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nico KaiserIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Fabian HaasIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Yusuke OkabayashiIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Dominik KyliesIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Smilla HofmannIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rossana FranzinSection of Nephrology, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Niklas SabraIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sarah BouariErasmus MC Transplant Institute, Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands.
Yitian FangErasmus MC Transplant Institute, Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands.
Gisela AmbagtsheerErasmus MC Transplant Institute, Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands.
Ilka EdenhoferIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Silvia ChillaIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anne K MühligIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marina ZimmermannHamburg Center for Kidney Health (HCKH), Hamburg, Germany.
Milagros N WongIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Takashi YokooDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Oliver KretzIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Maja LindenmeyerIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Florian GrahammerIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Martin J HoogduijnErasmus MC Transplant Institute, Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands.
Ron de BruinErasmus MC Transplant Institute, Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands.
Malte KuehlIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sonja HänzelmannIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bernd KammererCore Competence Metabolomics, Hilde-Mangold-Haus, and.
Loreto GesualdoSection of Nephrology, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Stefan BonnHamburg Center for Kidney Health (HCKH), Hamburg, Germany.
Robert C MinneeErasmus MC Transplant Institute, Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands.
Tobias B HuberIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Victor G PuellesIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Normothermic machine perfusion (NMP) has become a valuable tool to expand the pool of transplantable organs. However, the application of NMP to kidneys presents substantial challenges, mostly due to high variability in the composition of currently used perfusion solutions. Here, we provide a multimodal cross-species cellular atlas of kidney injury associated with NMP using a literature-based consensus buffer. This resource provided a systematic framework that was used to develop a metabolite-enhanced perfusion solution, which protected renal proximal tubular cells, improving cellular viability and transplantation outcomes across species, including human kidneys.

Indexed as

Kidney TransplantationOrgan PreservationOrgan Preservation SolutionsPerfusionAnimalsCell SurvivalGraft SurvivalHumansKidneyKidney Tubules, ProximalReperfusion InjuryOrgan Preservation SolutionsAmino acid metabolismApoptosis pathwaysCell biologyMetabolismNephrologyOrgan transplantation

Identifiers

PMID40985893
PMCPMC12487851

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.