Evidence map›Paper›PMID 40985891›Full record

ArticleJCI insight2025

Air pollution modulates brown adipose tissue function through epigenetic regulation by HDAC9 and KDM2B.

Rengasamy Palanivel, Jean-Eudes Dazard, Bongsoo Park, Sarah Costantino, Skanda T Moorthy, Armando Vergara-Martel, Elaine Ann Cara, Jonnelle Edwards-Glenn, Shyam Biswal, Lung Chi Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rengasamy PalanivelCardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Jean-Eudes DazardCardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Bongsoo ParkTranslational Gerontology Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA.
Sarah CostantinoCenter for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich and University of Zurich, Schlieren, Switzerland.
Skanda T MoorthyCardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Armando Vergara-MartelCardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Elaine Ann CaraCardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Jonnelle Edwards-GlennCardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Shyam BiswalDepartment of Environmental Health and Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Lung Chi ChenDepartment of Environmental Medicine, New York University School of Medicine, New York, New York, USA.
Mukesh K JainDivision of Biology and Medicine, Brown University, Providence, Rhode Island, USA.
Francesco PaneniCenter for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich and University of Zurich, Schlieren, Switzerland.
Sanjay RajagopalanCardiovascular Research Institute, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

Funding

Diversity Suppplement (CIRCADIAN) Circadian Disruption as Mediator of Cardiometabolic Risk in Air PollutionR35ES031702 · NIEHS · CASE WESTERN RESERVE UNIVERSITY · PI Sanjay Rajagopalan · 2021 to 2026
$5.9M
Environmental Triggers of Cardiometabolic DiseaseR01ES019616 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI BROOK, ROBERT DANIEL, RAJAGOPALAN, SANJAY · 2011 to 2020
$3.0M
Targets and targeting of immunometabolism in chronic PM2.5 exposureR01ES033670 · NIEHS · CASE WESTERN RESERVE UNIVERSITY · PI Andrei Maiseyeu, Sanjay Rajagopalan · 2022 to 2026
$2.2M
Diet-Environment Interactions in InflammationR01ES017290 · NIEHS · UNIVERSITY OF MARYLAND BALTIMORE · PI RAJAGOPALAN, SANJAY · 2010 to 2014
$1.8M
NIEHS NIH HHS R01 ES017290NIEHS NIH HHS R01 ES019616NIEHS NIH HHS R01 ES033670NIEHS NIH HHS R35 ES031702
6 · The paper itself

Abstract

Recent experimental and epidemiologic data have strongly associated air pollution in the pathogenesis of insulin resistance and type 2 diabetes mellitus. We explored the effect of inhalational exposure to concentrated ambient particulate matter smaller than 2.5 μm (PM2.5), or filtered air, using a whole-body inhalation system (6 hours/day, 5 days/week) for 24 weeks on metabolism and brown adipose tissue (BAT) function. Mechanistic evaluation of insulin resistance, glucose uptake with 18F-fluorodeoxyglucose positron emission tomography, alongside evaluation for differentially methylated regions, chromatin accessibility, and differential expression of genes was performed. PM2.5 exposure impaired metabolism through changes in key BAT transcriptional programs involved in redox stress, lipid deposition, fibrosis, and altered thermogenesis. Significant differential methylation and widespread chromatin remodeling was noted in BAT with PM2.5. Integrated analysis uncovered a role for the histone deacetylase HDAC9 and histone demethylase KDM2B. The latter demethylates Lys-4 and Lys-36 of histone H3. Specifically, studies using ChIP combined with quantitative PCR confirmed HDAC9 and KDM2B occupancy and reduced H3K36me2 on the promoter of target BAT genes in PM2.5 mice, while Hdac9/Kdm2b knockdown and overexpression increased and reduced BAT metabolism, respectively. Collectively, our results provide insights into air pollution exposure and changes in BAT and metabolism.

Indexed as

Adipose Tissue, BrownAir PollutionEpigenesis, GeneticHistone DeacetylasesJumonji Domain-Containing Histone DemethylasesParticulate MatterRepressor ProteinsAnimalsDNA MethylationHistonesInsulin ResistanceMaleMiceMice, Inbred C57BLThermogenesisHistone DeacetylasesHistonesJumonji Domain-Containing Histone DemethylasesParticulate MatterRepressor ProteinsAdipose tissueCell biologyEpigeneticsGlucose metabolismMetabolism

Identifiers

PMID40985891
PMCPMC12548086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.