Evidence map›Paper›PMID 40985835›Full record

ReviewRadiology2025

Best Practices for the Safe Use of Large Language Models and Other Generative AI in Radiology.

Paul H Yi, Hana L Haver, Jean J Jeudy, Woojin Kim, Felipe C Kitamura, Eniola T Oluyemi, Andrew D Smith, Linda Moy, Vishwa S Parekh

Abstract readReview
In one paragraph

Review in Radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paul H YiDepartment of Radiology, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105-3678.ORCID 0000-0001-9433-8093
Hana L HaverDepartment of Radiology, Brigham and Women's Hospital, Boston, Mass.ORCID 0000-0002-8382-4077
Jean J JeudyDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md.ORCID 0000-0002-6028-459X
Woojin KimDepartment of Radiology, Palo Alto VA Medical Center, Palo Alto, Calif.ORCID 0000-0002-7975-9145
Felipe C KitamuraDepartment of Diagnostic Imaging, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID 0000-0002-9992-5630
Eniola T OluyemiThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Md.ORCID 0000-0001-8956-4379
Andrew D SmithDepartment of Radiology, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105-3678.ORCID 0000-0002-8124-1038
Linda MoyDepartment of Radiology, New York University Grossman School of Medicine, New York, NY.ORCID 0000-0001-9564-9360
Vishwa S ParekhDepartment of Diagnostic & Interventional Imaging, McGovern Medical School, University of Texas Health Science Center, Houston, Tex.ORCID 0000-0002-6306-0305

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As large language models (LLMs) and other generative artificial intelligence (AI) models are rapidly integrated into radiology workflows, unique pitfalls threatening their safe use have emerged. Problems with AI are often identified only after public release, highlighting the need for preventive measures to mitigate negative impacts and ensure safe, effective deployment into clinical settings. This article summarizes best practices for the safe use of LLMs and other generative AI models in radiology, focusing on three key areas that can lead to pitfalls if overlooked: regulatory issues, data privacy, and bias. To address these areas and minimize risk to patients, radiologists must examine all potential failure modes and ensure vendor transparency. These best practices are based on the best available evidence and the experiences of leaders in the field. Ultimately, this article provides actionable guidelines for radiologists, radiology departments, and vendors using and integrating generative AI into radiology workflows, offering a framework to prevent these problems.

Indexed as

Artificial IntelligencePractice Guidelines as TopicRadiologyHumansLarge Language ModelsWorkflow

Identifiers

PMID40985835
PMCPMC12501631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.