Evidence map›Paper›PMID 40985781›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Active Transport of Macrocycles into Micelles Using Molecular Pumps.

James S W Seale, Swagat Sharma, Christopher K Lee, Han Han, Tyler Jaynes, Eric W Roth, Saman Shafie, Yunyan Qiu, Luke Malaisrie, Madison I Bardot and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Active Transport of Macrocycles into Micelles Using Molecular Pumps.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

James S W SealeDepartment of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA.ORCID 0000-0001-8086-6020
Swagat SharmaDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, 60208, USA.ORCID 0000-0002-4829-594X
Christopher K LeeSchool of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
Han HanDepartment of Chemistry, The University of Hong Kong, Hong Kong SAR, China.
Tyler JaynesDepartment of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA.ORCID 0000-0001-6084-1870
Eric W RothDepartment of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA.
Saman ShafieDepartment of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA.
Yunyan QiuDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, Republic of Singapore, 117543.ORCID 0000-0001-9279-4714
Luke MalaisrieDepartment of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA.
Madison I BardotDepartment of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA.ORCID 0000-0001-8655-6947
Long ZhangDepartment of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA.
Yi-Kang XingDepartment of Chemistry, The University of Hong Kong, Hong Kong SAR, China.
Dong Jun KimSchool of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia.
Samuel I StuppDepartment of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA.ORCID 0000-0002-5491-7442
R Dean AstumianDepartment of Physics and Astronomy, University of Maine, Orono, ME, USA.ORCID 0000-0001-7472-187X
Evan A ScottDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, 60208, USA.
William R DichtelDepartment of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA.ORCID 0000-0002-3635-6119
J Fraser StoddartDepartment of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA.ORCID 0000-0003-3161-3697

Funding

STRUCTURAL BIOL RES: LUNG SURFACTANT PROTEINS, DISTRESSS10RR019071 · NCRR · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2005 to 2005
$272k
600 MHz NMR Instrument Upgrade at Northwestern UniversityS10OD012016 · OD · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2012 to 2012
$267k
IIN, and Northwestern's MRSEC program DMR-2308691NCRR NIH HHS S10 RR019071NIH HHS S10 OD012016SHyNE Resource ECCS-2025633Soft and Hybrid Nanotechnology Experimental 1S10OD012016-01 / 1S10RR019071-01A1Soft and Hybrid Nanotechnology Experimental ECCS-2025633U.S. Department of Energy (DOE), Office of Science, Basic Energy Sciences DE-SC0020884
6 · The paper itself

Abstract

During the past decade, researchers have designed and synthesised a variety of artificial molecular pumps capable of the active transport of macrocycles (rings) from free solution into mechanically interlocked states. In their ability to drive non-equilibrium transport, these artificial molecular pumps imitate natural transmembrane transporters, which are widespread in living organisms. Despite this resemblance, ring-threading molecular pumps have not previously been operated in aqueous supramolecular assemblies in imitation of their natural counterparts. Here, we demonstrate the active transport of charged macrocycles from aqueous solution into micellar assemblies of polymer chains, which remain stable after pumping has occurred. While micelles are used routinely to encapsulate and solubilise hydrophobic small molecules in aqueous solution, this report, by contrast, shows that artificial molecular pumps can harness external energy to drive hydrophilic molecules into micelles where they are stored at concentrations far from equilibrium.

Indexed as

Macrocyclic CompoundsMicellesHydrophobic and Hydrophilic InteractionsPolymersMacrocyclic CompoundsMicellesPolymersActive transportArtificial molecular machinesArtificial molecular pumpsMicellesNonequilibrium processes

Identifiers

PMID40985781
PMCPMC12603975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.