Evidence map›Paper›PMID 40985722›Full record

ArticleJournal of virology2025

LPS/TLR4-activated M1-polarized macrophage-derived exosomes enhance IBV vaccine efficacy in chickens.

Jun Zhou, Shikai Cai, Hongbin Huang, Fan Yang, Kexin Pan, Zhaoyang Sun, Yun Fan, Feng Wen, Limei Qin, Yun Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jun Zhou *Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Shikai Cai *Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Hongbin HuangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Fan YangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Kexin PanGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Zhaoyang SunGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Yun FanGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.
Feng WenGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.ORCID 0000-0001-8790-1503
Limei QinGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan, China.ORCID 0000-0002-2511-7366
Yun ZhangHainan University Massey International College, Hainan University, Haikou, China.ORCID 0000-0001-5497-0107

Funding

National Natural Science Foundation of China 32202782Natural Science Foundation of Guangdong Province 2021A1515012388
6 · The paper itself

Abstract

Infectious bronchitis virus (IBV) imposes substantial economic losses on poultry production due to extensive serotypic diversity and limited cross-protection conferred by conventional vaccines. This study evaluated exosomes derived from M1-polarized chicken macrophages (HD11

Indexed as

Coronavirus InfectionsExosomesInfectious bronchitis virusMacrophagesPoultry DiseasesToll-Like Receptor 4Viral VaccinesAdjuvants, ImmunologicAnimalsAntibodies, ViralChickensCytokinesImmunity, HumoralLipopolysaccharidesPhagocytosisVaccinationAdjuvants, ImmunologicAntibodies, ViralCytokinesLipopolysaccharidesToll-Like Receptor 4Viral Vaccinesadjuvantattenuated vaccineavian infectious bronchitisexosomesimmunostimulantmacrophage

Identifiers

PMID40985722
PMCPMC12548463

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.