Evidence map›Paper›PMID 40985633›Full record

ArticleApplied and environmental microbiology2025

Contribution of UbrA, a ubiquitin ligase essential for Arg/N-degron pathway, to peptidase gene expression in

Waka Muromachi, Mao Ohba, Yasuaki Kawarasaki, Youhei Yamagata, Mizuki Tanaka

Abstract read
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In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Waka MuromachiDepartment of Applied Biological Chemistry, Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
Mao OhbaBiomolecular Engineering Laboratory, School of Food and Nutritional Science, University of Shizuoka, Shizuoka, Japan.
Yasuaki KawarasakiBiomolecular Engineering Laboratory, School of Food and Nutritional Science, University of Shizuoka, Shizuoka, Japan.ORCID 0000-0002-7143-3159
Youhei YamagataDepartment of Applied Biological Chemistry, Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
Mizuki TanakaDepartment of Applied Biological Chemistry, Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.ORCID 0000-0002-6302-323X

Funding

Institute for Fermentation, Osaka 2023-P38Japan Society for the Promotion of Science 17H07001Japan Society for the Promotion of Science 25K01928Mayekawa Houonkai Foundation 2022-1-1Noda Institute for Scientific Research 2021-2-5
6 · The paper itself

Abstract

The degradation of intracellular proteins by N-degron pathways depends on their N-terminal amino acids. In budding yeast, the Arg/N-degron pathway controls the expression of dipeptide/tripeptide transporter gene by degrading a transcriptional repressor. However, there is no detailed information on the N-degron pathway in filamentous fungi, and its role in regulating microbial nitrogen metabolism is unclear. Here, we demonstrated that the E3 ubiquitin ligase, UbrA, which is required for the Arg/N-degron pathway, regulates peptidase gene expression in the filamentous fungus IMPORTANCE: Peptidases produced by

Indexed as

ArginineAspergillus oryzaeFungal ProteinsGene Expression Regulation, FungalPeptide HydrolasesUbiquitin-Protein LigasesDegronsNitrogenArginineFungal ProteinsNitrogenPeptide HydrolasesUbiquitin-Protein Ligasesalkaline peptidaseAspergillus oryzaecarboxypeptidasedipeptide/tripeptide transporterdipeptidyl peptidaseendopeptidaseN-degron pathwaytripeptidyl peptidaseubiquitin ligase

Identifiers

PMID40985633
PMCPMC12542663

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.