Evidence map›Paper›PMID 40985453›Full record

ArticleJournal of fungi (Basel, Switzerland)2025

Evolutionary History and Distribution Analysis of Rhamnosyltransferases in the Fungal Kingdom.

Joaquín O Chávez-Santiago, Luz A López-Ramírez, Luis A Pérez-García, Iván Martínez-Duncker, Bernardo Franco, Israel E Padilla-Guerrero, Vianey Olmedo-Monfil, J Félix Gutiérrez-Corona, Gustavo A Niño-Vega, Jorge H Ramírez-Prado and 1 more

Abstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joaquín O Chávez-SantiagoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato 36050, Guanajuato, Mexico.
Luz A López-RamírezDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato 36050, Guanajuato, Mexico.
Luis A Pérez-GarcíaFacultad de Estudios Profesionales Zona Huasteca, Universidad Autónoma de San Luis Potosí, Romualdo del Campo 501, Fracc. Rafael Curiel, Ciudad Valles 79060, San Luis Potosí, Mexico.ORCID 0000-0002-5800-2987
Iván Martínez-DunckerLaboratorio de Glicobiología Humana y Diagnóstico Molecular, Centro de Investigación en Dinámica Celular, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, Morelos, Mexico.
Bernardo FrancoDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato 36050, Guanajuato, Mexico.ORCID 0000-0003-4332-3734
Israel E Padilla-GuerreroDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato 36050, Guanajuato, Mexico.ORCID 0000-0002-7078-2664
Vianey Olmedo-MonfilDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato 36050, Guanajuato, Mexico.ORCID 0000-0002-3324-1025
J Félix Gutiérrez-CoronaDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato 36050, Guanajuato, Mexico.ORCID 0000-0003-0808-6040
Gustavo A Niño-VegaDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato 36050, Guanajuato, Mexico.ORCID 0000-0003-3760-5620
Jorge H Ramírez-PradoUnidad de Biotecnología, Centro de Investigación Científica de Yucatán, A. C., Calle 43 No. 130, Col. Chuburná de Hidalgo, Mérida 97205, Yucatán, Mexico.ORCID 0000-0003-2780-5223
Héctor M Mora-MontesDepartamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato 36050, Guanajuato, Mexico.ORCID 0000-0001-6973-0595

Funding

Red Temática Glicociencia en Salud CONACYT-MéxicoSecretaría de Ciencia, Humanidades, Tecnología e Innovación CBF2023-2024-655Secretaría de Ciencia, Humanidades, Tecnología e Innovación Ciencia de Frontera 2019-6380
6 · The paper itself

Abstract

Rhamnose is a natural sugar found in glycoproteins and structural polysaccharides of plants, fungi, and bacteria. Its incorporation into glycoconjugates is mediated by rhamnosyltransferases (RHTs), key enzymes for biomolecular stability and function. While rhamnose biosynthesis has been studied in certain fungal genera, the evolutionary history and distribution of RHTs across the fungal kingdom remain largely unknown. In this study, 351 fungal species were found to encode putative RHTs. Phylogenetic and structural analyses revealed conserved patterns and similarities with previously characterized RHTs. Molecular docking predicted a high affinity of these proteins for UDP-L-rhamnose, and in silico mutagenesis identified key residues potentially involved in substrate binding. Carbohydrate profiling confirmed the presence of rhamnose in the cell walls of multiple fungi, including

Indexed as

evolutionary historyfungal kingdomhidden Markov modelsprotein glycosylationrhamnosyltransferases

Identifiers

PMID40985453
PMCPMC12295706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.