Evidence map›Paper›PMID 40985382›Full record

ArticleJournal of fungi (Basel, Switzerland)2025

Pneumocystis Pneumonia in Cirrhosis: An Underrecognized Fungal Infection in a Vulnerable Host.

Aaron M Pulsipher, Michele Barnhill, Holenarasipur R Vikram, Michael B Gotway, Rodrigo Cartin-Ceba, Kevin Zhou, Emily R Thompson, Andrew H Limper, Bashar Aqel, Kealy Ham

Abstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Are CD4Livers · 2026
    Article
  2. An Observational Analysis of a Large Cohort ofOpen forum infectious diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aaron M PulsipherDepartment of Critical Care, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0009-0000-8225-1361
Michele BarnhillDivision of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, AZ 85054, USA.
Holenarasipur R VikramDivision of Infectious Diseases and Transplant Center, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0000-0002-6391-0349
Michael B GotwayDivision of Cardiothoracic Radiology, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0000-0002-7090-3825
Rodrigo Cartin-CebaDepartment of Critical Care, Mayo Clinic, Phoenix, AZ 85054, USA.
Kevin ZhouDepartment of Internal Medicine, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0000-0001-9218-6743
Emily R ThompsonDivision of Clinical Trials and Biostatistics, Mayo Clinic Arizona, Phoenix, AZ 85054, USA.ORCID 0009-0009-6066-8241
Andrew H LimperDivision of Pulmonary and Critical Care, Mayo Clinic, Rochester, MN 55905, USA.
Bashar AqelDivision of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0000-0002-9671-9575
Kealy HamDepartment of Critical Care, Mayo Clinic, Phoenix, AZ 85054, USA.ORCID 0009-0003-7085-5530

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
Pneumocystis: Macrophage & Epithelial ActivationR01HL062150 · NHLBI · MAYO CLINIC ROCHESTER · PI ANDREW H LIMPER · 1998 to 2026
$9.2M
The Role of the EphA2 Receptor Kinase Pathway in Pneumocystis Pneumonia (PCP)R21AI181542 · NIAID · MAYO CLINIC ROCHESTER · PI LIMPER, ANDREW H · 2024 to 2025
$438k
NCATS NIH HHS UL1 TR002377NHLBI NIH HHS R01 HL062150NIAID NIH HHS R21 AI181542
6 · The paper itself

Abstract

Pneumocystis pneumonia (PCP) is a serious fungal infection affecting immunocompromised hosts. Decompensated cirrhosis leads to cirrhosis-associated immune dysfunction (CAID), a form of impaired cellular immunity that may predispose patients to opportunistic infections such as PCP. We conducted a retrospective review of 727 patients with proven or probable PCP from 2017 to 2025. Of these, 33 had decompensated cirrhosis. These patients were stratified into two groups: Cirrhosis Only (n = 16) and Cirrhosis with Additional Immunocompromising Conditions (n = 17). Among the patients with cirrhosis, the overall mortality was 48%, with the 90-day mortality reaching 57.6% (95% CI: 39.2-74.5%). Compared with those without cirrhosis, the patients with cirrhosis had a higher risk of mortality (OR: 4.08, 95% CI: 2.01-8.30,

Indexed as

antifungal prophylaxischronic liver failurecirrhosis-associated immune dysfunctionimmunocompromised hostopportunistic infections

Identifiers

PMID40985382
PMCPMC12298041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.