ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Application of multi-omics in systemic autoimmune rheumatic diseases: a bibliometric and visualization analysis.Frontiers in immunology · 2026Pooled it
- Multi-cohort Analysis Reveals Microbiome Signatures Associated with Drug Response in New-Onset Rheumatoid Arthritis.bioRxiv : the preprint server for biology · 2026Article
- Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modified Jiaoqi powder ameliorates ulcerative colitis through gut microbiota-tryptophan metabolism-AhR signaling modulating-ILC2/ILC3 balance.Frontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
27 authors.
Funding
Abstract
Rheumatoid arthritis (RA) is a autoimmune disease characterized by heterogeneity in response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). This study aims to elucidate molecular differences in response mechanisms of RA patients to csDMARDs through multiomics approach, with particular focus on the role of tryptophan (Trp) in treatment. Plasma, fecal, and peripheral blood mononuclear cells (PBMCs) were collected for metabolomics, microbiomics, transcriptomics, single-cell transcriptomics, proteomics, and phosphoproteomics analyses. Additionally, in vitro/vivo experiments and controlled clinical trial were conducted to validate the findings. Comprehensive analysis revealed significant alterations in Trp-related metabolic profiles, microbiota composition, and immune cells, indicating the role of Trp in modulating therapeutic response to csDMARDs. In vitro experiments demonstrated that Trp significantly inhibited the proliferation of MH7A and PBMCs while reducing the secretion of IL-1β, IL-6, and TNF-α. Furthermore, in vivo studies showed that Trp treatment decreased arthritis scores and histological scores in mice. Clinical data further confirmed that dietary supplementation with Trp significantly improved disease activity scores and alleviated inflammatory in RA patients. This study highlights the crucial regulatory role of Trp in RA therapy, providing novel insights for optimizing clinical treatment strategies for RA.
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