ArticleChembiochem : a European journal of chemical biology2025
Aldehyde or Hydrate? Investigation into the Oxidation of 5-Formylcytosine Derivatives Using a Computational and Experimental Approach.
Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Thermodynamic Mapping of C5-Substituent Autoxidation Pathways in 1,5-Dimethylcytosine: A Quantum Chemical Study.Journal of computational chemistry · 2026Article
- Aldehyde or Hydrate? Investigation into the Oxidation of 5-Formylcytosine Derivatives Using a Computational and Experimental Approach.Chembiochem : a European journal of chemical biology · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
This study investigates the oxidation of 5-hydroxymethyl and 5-formyl nucleobases using an iron(IV)-oxido complex that mimics the function of TET enzymes. A central question in this context is whether the oxidation of formyl substrates proceeds via the aldehyde or the hydrate form. To investigate the possible different reaction kinetics of these two forms, nucleobases containing a 6-aza-moiety are employed, giving rise to significantly more aldehyde hydrate as compared to the unaltered nucleobase. The concentration changes of substrates and products during oxidation were followed with
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