Evidence map›Paper›PMID 40985252›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2026

Pelvi-Ureteric Junction Obstruction in a Solitary Functioning Kidney in Children: An Unfavourable Combination.

Mathilde Grapin, Lucas Rabaux, Mathilde Glenisson, Eva Mille, Nathalie Biebuyck, Evgenia Preka, Olivia Boyer, Kiarash Taghavi, Guillaume Dorval, Thomas Blanc

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Article in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Mathilde GrapinDepartment of Pediatric Nephrology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, Reference Center for Inherited Renal Diseases (MARHEA), Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Lucas RabauxDepartment of Pediatric Surgery and Urology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Mathilde GlenissonDepartment of Pediatric Surgery and Urology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Eva MilleDepartment of Pediatric Surgery and Urology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Nathalie BiebuyckDepartment of Pediatric Nephrology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, Reference Center for Inherited Renal Diseases (MARHEA), Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Evgenia PrekaDepartment of Pediatric Nephrology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, Reference Center for Inherited Renal Diseases (MARHEA), Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Olivia BoyerDepartment of Pediatric Nephrology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, Reference Center for Inherited Renal Diseases (MARHEA), Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Kiarash TaghaviDepartment of Pediatric Surgery and Urology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID 0000-0002-1837-9966
Guillaume DorvalDepartment of Pediatric Nephrology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France, Reference Center for Inherited Renal Diseases (MARHEA), Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.
Thomas BlancDepartment of Pediatric Surgery and Urology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.ORCID 0000-0002-5829-8167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimSolitary functioning kidney (SFK) is linked to chronic kidney disease (CKD) in children, particularly when associated with congenital anomalies of the kidney and urinary tract (CAKUT). Pelvi-ureteric junction obstruction (PUJO) is the most frequent obstructive uropathy in SFK. This study aimed to evaluate long-term kidney function in children operated on for PUJO in an SFK.

methodsAmong a retrospective cohort study of children with an SFK, a subgroup analysis was performed: primary SFK with operated PUJO (n = 35); primary SFK without CAKUT (n = 108); primary SFK with CAKUT other than PUJO (n = 24). Markers of CKD and measured glomerular filtration rate were assessed during follow-up.

resultsSurgery was indicated because of neonatal acute kidney injury (AKI) (n = 21), worsening renal pelvis dilation (n = 10). The median age at surgery was 15 months (1.2-30 months). At a median age of 13 years at last follow-up, the proportion of CKD was higher in primary SFK with PUJO compared to primary SFK without CAKUT (43% vs. 12%, p = 0.0008). In SFK/PUJO, neonatal AKI was predictive of subsequent CKD (OR 4.8, p = 0.04).

conclusionPUJO in an SFK is associated with a high rate of CKD during childhood, particularly when neonatal AKI is present.

Indexed as

Kidney PelvisRenal Insufficiency, ChronicSolitary KidneyUreteral ObstructionAdolescentChildChild, PreschoolFemaleGlomerular Filtration RateHumansInfantMaleRetrospective Studieschronic kidney diseasecongenital anomalies of the kidney and urinary tractglomerular filtration ratepaediatricssolitary functioning kidneyureteropelvic junction obstruction

Identifiers

PMID40985252
PMCPMC12687707

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.