Evidence map›Paper›PMID 40985182›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Single-Cell Transcriptomics Reveals ITGA2-Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis.

Zhi-Jun Zhan, Ning Li, Yan Sun, Lu Chen, Jun-da Yin, Yun-Han Shan, Jia-Xing Zeng, Zhe-Cheng Li, Hai-Long Tan, Neng Tang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhi-Jun ZhanDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.
Ning LiDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.ORCID https://orcid.org/0000-0002-3477-2194
Yan SunDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.
Lu ChenDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.
Jun-da YinDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.
Yun-Han ShanDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.
Jia-Xing ZengDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.
Zhe-Cheng LiDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.
Hai-Long TanDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.
Neng TangDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.
Shi ChangDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.
Peng HuangDepartment of General Surgery, XiangYa Hospital Central South University, Changsha, Hunan, 410008, China.ORCID https://orcid.org/0000-0003-3011-3359

Funding

Central Universities of Central South University 2024ZZTS0871Construction of Innovative Provinces in Hunan 2024JK2140National Natural Science Foundation of China 82371602National Natural Science Foundation of China 82472881Natural Science Foundation of Hunan Province 2024JJ5563Postgraduate Scientific Research Innovation Project of Hunan Province QL20230043Postgraduate Scientific Research Innovation Project of Hunan Province QL20230044
6 · The paper itself

Abstract

Pediatric papillary thyroid carcinoma (PPTC) has exhibited a progressive increase in incidence in recent years, characterized by heightened biological aggressiveness relative to adult papillary thyroid carcinoma (APTC). Nevertheless, the molecular mechanisms governing PPTC-specific pathobiology remain elusive. Through high-resolution single-cell RNA sequencing analysis of 90234 cellular transcriptomes from 4 PPTC and 9 APTC clinical specimens, a phenotypically distinct cellular subpopulation (ITGA2

Indexed as

CarcinogenesisIntegrin alpha2Thyroid Cancer, PapillaryThyroid NeoplasmsTranscriptomeChildFemaleHumansMaleMetabolic ReprogrammingSingle-Cell AnalysisIntegrin alpha2glycolysisheterogeneitylandscapemacrophagespediatric thyroid carcinoma

Identifiers

PMID40985182
PMCPMC12677704

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.