Evidence map›Paper›PMID 40985115›Full record

ArticleFEBS open bio2026

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non-small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival.

Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stuti GoelChemistry Department, Eastern Michigan University, Ypsilanti, MI, USA.
Caroline WozniakChemistry Department, Eastern Michigan University, Ypsilanti, MI, USA.
Aya SabriChemistry Department, Eastern Michigan University, Ypsilanti, MI, USA.
Ben HaddadChemistry Department, Eastern Michigan University, Ypsilanti, MI, USA.
Brooke LopoChemistry Department, Eastern Michigan University, Ypsilanti, MI, USA.
Alvaro CobosChemistry Department, Eastern Michigan University, Ypsilanti, MI, USA.
Sarah SarofimChemistry Department, Eastern Michigan University, Ypsilanti, MI, USA.
Jeffrey GuthrieChemistry Department, Eastern Michigan University, Ypsilanti, MI, USA.
Deborah HeylChemistry Department, Eastern Michigan University, Ypsilanti, MI, USA.
Hedeel Guy EvansChemistry Department, Eastern Michigan University, Ypsilanti, MI, USA.ORCID https://orcid.org/0000-0002-7970-9084

Funding

Probing the Role of Insulin-Like Growth Factor-Binding Protein 3 and Humanin in Regulating Hyaluronan FunctionR15GM131222 · NIGMS · EASTERN MICHIGAN UNIVERSITY · PI GUY EVANS, HEDEEL I. · 2019 to 2025
$1.5M
NIGMS NIH HHS R15 GM131222NIH HHS R15GM131222
6 · The paper itself

Abstract

Lactoferrin (Lf) is a multifunctional glycoprotein of the transferrin family which has shown to efficiently block cell migration and/or invasion in a wide range of cancer cell models. The objective of this study was to further understand how Lf targets cancer cells by examining the effect of acetylcholine (ACh) levels on Lf signaling using A549 (p53 wild-type) and H1299 (p53-null) nonsmall cell lung cancer (NSCLC) cell lines. Treatment with Lf reduced cell viability more effectively in A549 cells than in H1299 cells. The half maximal inhibitory concentration (IC

Indexed as

AcetylcholineAcetylcholinesteraseCarcinoma, Non-Small-Cell LungLactoferrinLung NeoplasmsA549 CellsApoptosisCell Line, TumorCell SurvivalCulture Media, ConditionedHumansSignal TransductionTumor Suppressor Protein p53Vascular Endothelial Growth Factor AAcetylcholineAcetylcholinesteraseCulture Media, ConditionedLactoferrinTumor Suppressor Protein p53Vascular Endothelial Growth Factor Aacetylcholinecell viabilitylactoferrinlung cancerp53vascular endothelial growth factor

Identifiers

PMID40985115
PMCPMC12871553

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.