Evidence map›Paper›PMID 40985010›Full record

ArticlemicroPublication biology2025

CD320 expression is increased in breast cancer stem cells but does not promote their expansion or alter key histone methylation marks.

Christine Carney, Lisa Jenkins, Connor Jewell, Rachel Carter, Puneet Mann, Binwu Tang, Senthil Muthuswamy, Lalage Wakefield

Abstract read
In one paragraph

Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christine CarneyNational Cancer Institute, Bethesda, Maryland, United States.
Lisa JenkinsNational Cancer Institute, Bethesda, Maryland, United States.
Connor JewellNational Cancer Institute, Bethesda, Maryland, United States.
Rachel CarterNational Cancer Institute, Bethesda, Maryland, United States.
Puneet MannNational Cancer Institute, Bethesda, Maryland, United States.
Binwu TangNational Cancer Institute, Bethesda, Maryland, United States.
Senthil MuthuswamyNational Cancer Institute, Bethesda, Maryland, United States.
Lalage WakefieldNational Cancer Institute, Bethesda, Maryland, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several lines of evidence suggest a potential link between stemness and vitamin B12, which contributes to S-adenosylmethionine (SAM) generation and hence methylation-dependent epigenetic control. Here we found that the vitamin B12 receptor, CD320, is significantly increased in cancer stem cells (CSCs) in models of triple-negative breast cancer

Identifiers

PMID40985010
PMCPMC12450303

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.