Evidence map›Paper›PMID 40985002›Full record

ReviewEuropean heart journal. Digital health2025

Artificial intelligence applications in hypertrophic cardiomyopathy: turns and loopholes.

Giorgia Panichella, Manuel Garofalo, Laura Sasso, Alessandra Milazzo, Alessandra Fornaro, Josè Manuel Pioner, Alfonso Bueno-Orovio, Mark van Gils, Annariina Koivu, Luca Mainardi and 7 more

Abstract readReview
In one paragraph

Review in European heart journal. Digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Cardiovascular magnetic resonance for therapy monitoring in cardiomyopathies.European heart journal. Imaging methods and practice · 2026
    Review
  3. Assessing Quality of Life in Genetic Cardiomyopathies: A Scoping Review.International journal of environmental research and public health · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Giorgia PanichellaDepartment of Experimental and Clinical Medicine, University of Florence, Viale Morgagni, 63, Florence 50134, Italy.ORCID https://orcid.org/0000-0002-9049-5320
Manuel GarofaloDepartment of Experimental and Clinical Medicine, University of Florence, Viale Morgagni, 63, Florence 50134, Italy.
Laura SassoCardiomyopathy Unit, Careggi University Hospital, Largo Giovanni Alessandro Brambilla, 1, Florence 50134, Italy.
Alessandra MilazzoDepartment of Experimental and Clinical Medicine, University of Florence, Viale Morgagni, 63, Florence 50134, Italy.ORCID https://orcid.org/0000-0002-3334-9298
Alessandra FornaroCardiomyopathy Unit, Careggi University Hospital, Largo Giovanni Alessandro Brambilla, 1, Florence 50134, Italy.
Josè Manuel PionerDepartment of Biology, University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0003-0179-3033
Alfonso Bueno-OrovioDepartment of Computer Science, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-1634-3601
Mark van GilsFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Annariina KoivuFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Luca MainardiDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.
Virginie Le RolleDepartment of Cardiology, University of Rennes, CHU Rennes, Inserm, LTSI-UMR 1099  Rennes F-35000, France.ORCID https://orcid.org/0000-0003-1068-5587
Felix AgakovPharmatics Limited, Edinburgh, United Kingdom.
Maurizio PieroniDepartment of Experimental and Clinical Medicine, University of Florence, Viale Morgagni, 63, Florence 50134, Italy.ORCID https://orcid.org/0000-0002-6830-4292
Katriina Aalto-SetäläFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Jari HyttinenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Iacopo OlivottoDepartment of Experimental and Clinical Medicine, University of Florence, Viale Morgagni, 63, Florence 50134, Italy.ORCID https://orcid.org/0000-0003-1751-9266
Annamaria Del FrancoCardiomyopathy Unit, Careggi University Hospital, Largo Giovanni Alessandro Brambilla, 1, Florence 50134, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease where, despite recent advances, accurate diagnosis, risk stratification, and personalized treatment remain challenging. Artificial intelligence (AI) offers a transformative approach to HCM by enabling rapid, precise analysis of complex data. This article reviews the current and potential applications of AI in HCM. AI enhances diagnostic accuracy by analysing electrocardiograms, echocardiography, and cardiac magnetic resonance images, differentiating HCM from other forms of left ventricular hypertrophy, identifying subtle phenotypic variations, and standardizing myocardial fibrosis assessment. Multimodal AI-driven approaches improve risk stratification, therapeutic decision-making, and monitoring of both established and novel therapies, such as cardiac myosin inhibitors. Emerging AI-driven

Indexed as

artificial intelligenceDeep learningDigital-twinHypertrophic cardiomyopathyLeft ventricular hypertrophyMachine learning

Identifiers

PMID40985002
PMCPMC12450525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.