ArticleCureus2025
Comparative Evaluation of Sodium Bicarbonate and Hyaluronidase as Adjuncts to Lignocaine in Peribulbar Block During Cataract Surgery.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Peribulbar anaesthesia is widely used in cataract surgery to provide reliable analgesia, akinesia, and a low rate of complications. Hyaluronidase is conventionally added to local anaesthetic solutions to enhance diffusion and improve block quality. More recently, sodium bicarbonate has been suggested as an alternative adjunct, as its alkalinising effect increases the proportion of non-ionised lignocaine, potentially accelerating onset and improving efficacy. This study aimed to compare the effectiveness of sodium bicarbonate and hyaluronidase as adjuncts to lignocaine in peribulbar block during cataract surgery, with particular focus on pain perception, onset of anaesthesia, and onset of akinesia. Materials and methods A randomised interventional study was conducted on 80 patients undergoing cataract surgery, divided equally into two groups of 40. Group A received a mixture of lignocaine, bupivacaine, and hyaluronidase, while Group B received lignocaine, bupivacaine, and sodium bicarbonate. Pain intensity was assessed using the Visual Analogue Scale (VAS), and the onset of anaesthesia and akinesia were recorded at one-minute intervals for up to 10 minutes. Data were analysed using IBM SPSS Statistics for Windows, Version 22.0 (IBM Corp., Armonk, NY, USA), with statistical significance set at p < 0.05. Results Patients in Group B reported significantly lower pain scores (p < 0.05) and a faster onset of anaesthesia compared to Group A. In contrast, the onset of akinesia was significantly slower in Group B. Complication rates were comparable between the two groups, with no statistically significant differences observed. Conclusion The findings suggest that sodium bicarbonate is a useful adjunct to lignocaine in peribulbar anaesthesia, offering faster onset and reduced pain perception, though its effect on akinesia requires further evaluation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.