ReviewCureus2025
Global Research Trends in Bladder Cancer Biomarkers: A Bibliometric Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bladder cancer has traditionally relied on cystoscopy, which is invasive and associated with patient morbidity, prompting extensive research into non-invasive biomarkers specific to bladder cancer. This study aims to map the global research trends in bladder cancer biomarkers over the last two decades using bibliometric analysis methodology. A total of 1337 articles from 2004 to 2024 were retrieved from Web of Science Core Collection and analysed using the Bibliometrix R Package (K-Synth Srl, Naples, Italy) and VOSviewer (Centre for Science and Technology Studies, Leiden University, The Netherlands). Research output in this field has grown from 21 publications in 2004 to a peak of 138 in 2021. China is the most productive country with 516 (38.6%) publications, and Sun Yat-sen University in Guangzhou, China, is the most productive institution. However, Spain, the United Kingdom, and Japan demonstrated greater research impact with higher average citations per paper. Shariat, SF, and Lotan, Y, are the two most influential authors in this field based on average citations and network analysis. Keywords analysis revealed a shift in research trends from established protein-based biomarkers such as NMP22 and UroVysion (Abbott Laboratories, Chicago, Illinois, United States) to novel genetic and epigenetic markers. Future studies should foster greater international collaboration in translating these novel biomarkers into routine clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.