Evidence map›Paper›PMID 40984734›Full record

ArticleDrug delivery2025

Sequential nanotheranostics based on hollow mesoporous silica loaded doxorubicin and seed kernel extract from

Arunsajee Sae-Be, Jiraporn Leanpolchareanchai, Piyaporn Plommaithong, Apichat Chatsukit, Shanapa Ratthanakanungthum, Kuntida Wongwattanasan, Tomoki Ota, Sarunyakorn Raowong, Pongtip Sithisarn, Savita Chewchinda and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biomimetic Scaffold-Based 3D Models for Decoding Cancer Biology and Advancing Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Arunsajee Sae-BeDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Jiraporn LeanpolchareanchaiDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Piyaporn PlommaithongDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Apichat ChatsukitDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Shanapa RatthanakanungthumDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Kuntida WongwattanasanDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Tomoki OtaDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Sarunyakorn RaowongDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Pongtip SithisarnDepartment of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Savita ChewchindaDepartment of Food Chemistry, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Parichart NaruphontjirakulBiological Engineering Program, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Teerasit TermsaithongLearning Institute, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Thana SutthibutpongTheoretical and Computational Physics Group (TCP), Center of Excellence in Theoretical and Computational Science (TaCS-CoE), Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Varaporn Buraphacheep JunyaprasertDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Khanit Sa-NgiamsuntornCentre of Molecular Targeting and Integrated Drug Development (CMT-IDD), Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Rapepol BavovadaDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
Pimolpan PithayanukulDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.
Alexandra E PorterDepartment of Materials and London Centre for Nanotechnology, Imperial College London, London, United Kingdom.
Pakatip RuenraroengsakDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Rajathevi, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mango seed kernel extract (MSKE) and its phytochemical compositions were investigated for their anticancer activities and synergistic effects with doxorubicin (DOX) against hepatocellular carcinoma (HCC) in both 2D and 3D culture models. Molecular docking studies were conducted to elucidate the mechanisms of DOX, MSKE, and major phytochemical components against overexpressed HCC-related proteins. Co-delivery of DOX and MSKE demonstrated significant synergistic anticancer activity in both models. A sequential nanotheranostic platform (SNP), consisting of MSKE encapsulated aminated hollow mesoporous silica nanoparticles capped with graphene quantum dots (GQD-MSKE-NH

Indexed as

Antineoplastic Agents, PhytogenicCarcinoma, HepatocellularLiver NeoplasmsMangiferaNanoparticle Drug Delivery SystemPlant ExtractsTheranostic NanomedicineAntibiotics, AntineoplasticChemotherapy, AdjuvantDoxorubicinDrug LiberationDrug Screening Assays, AntitumorDrug SynergismHep G2 CellsHumansMolecular Docking SimulationAntibiotics, AntineoplasticAntineoplastic Agents, PhytogenicDoxorubicinMangifera indica extractNanoparticle Drug Delivery SystemPlant ExtractsSilicon Dioxidecombination therapyHepatocellular carcinomahollow mesoporous silica nanoparticleMangifera indicananotheranosticssequential-delivery system

Identifiers

PMID40984734
PMCPMC12459191

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.