Trial reportJournal of Alzheimer's disease : JAD2025
Effectiveness and safety of high-definition transcranial direct current stimulation in patients with mild cognitive impairment: A randomized, triple-blind, sham-controlled trial.
Trial report in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Parietal and prefrontal transcranial magnetic stimulation (TMS) for mild cognitive impairment (MCI): A pilot randomized clinical trial.Brain disorders (Amsterdam, Netherlands) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundHigh-definition transcranial direct current stimulation (HD-tDCS), a non-invasive brain stimulation technique, has shown potential for improving cognition in patients with mild cognitive impairment (MCI).ObjectiveTo evaluate whether HD-tDCS enhances cognitive function in individuals with MCI.MethodsThis was a triple-blind, randomized, sham-controlled study. The anodal electrode was placed over the left dorsolateral prefrontal cortex (DLPFC) and surrounded by four cathode electrodes (2 mA for 25 min, daily for 10 sessions). Tests were performed at baseline, after 2-week stimulation, at 1 month, and at 3 months. The primary outcome was global cognition measured by Cognitive Abilities Screening Instrument and secondary outcomes included memory, language, executive function, and attention tests. Group differences were analyzed using linear mixed model (LMM).ResultsFifty patients with MCI were randomized to the sham (n = 25) and HD-tDCS groups (n = 25). No significant differences were observed between the HD-tDCS and sham groups in global cognition or other neuropsychological measures. However, subgroup analysis revealed a significant three-way interaction between apolipoprotein E (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.