ReviewJournal of cellular and molecular medicine2025
Advances and Deep Insights Into Lactylation: Essential Roles in Cellular Regulation and Disease Association.
Review in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The lactate-lactylation axis in acute kidney injury: mechanisms from metabolic reprogramming to epigenetic regulation and clinical therapeutic prospects.International urology and nephrology · 2026Review
- Lactylation Remodels Tumorigenesis, Immune Microenvironment, and Therapeutic Response.Current issues in molecular biology · 2026Review
- Lactylation: a metabolic-epigenetic driver in atherosclerosis pathogenesis and therapeutic targeting.Frontiers in cardiovascular medicine · 2026Review
- Advances and Deep Insights Into Lactylation: Essential Roles in Cellular Regulation and Disease Association.Journal of cellular and molecular medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Proteins exert biological functions not only depending on abundance but also on regulation. Lactylation is an important novel post-translational modification (PTM) that can affect protein structure and function, playing a crucial role in signal transduction, gene expression and cellular metabolism. Lactylation participates in the progression of various diseases, such as tumours, heart failure, myocardial infarction, renal fibrosis and Alzheimer's disease. These studies suggest that lactylation may mediate metabolic reprogramming and enhance cellular plasticity, providing new entry points for developing therapeutic approaches. This review introduces the progress on various aspects of lactylation, including mechanisms, regulations and disease associations, aiming to provide valuable insights and inspiration for further exploration of protein modification networks.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.