Observational studyBMC endocrine disorders2025
Soluble receptor for advanced glycation end product (sRAGE) levels in adolescents with obesity, insulin resistance and metabolic syndrome: A case-control study and the review of the literature.
Observational study in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06771986 (Soluble Advanced Glycation End Product), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Soluble Advanced Glycation End Product (sRAGE) Levels in Childhood Obesity
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Authors and funding
2 authors.
Funding
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Abstract
objectiveThe aim of this study is to evaluate sRAGE levels in adolescents with obesity, and to determine the relationship between sRAGE, insulin resistance, and metabolic syndrome in a case-control study.
methodsThirty adolescents with insulin resistance, 28 adolescents without insulin resistance between 10 and 18 years old and 30 Healthy gender and age matched control group were included in the study. Patients with a body mass index z-score above 2, comprised the obesity group. HOMA-IR value above 3.16 was accepted as insulin resistance. Metabolic syndrome was defined based on the International Diabetes Federation definition.
resultssRAGE levels of the both groups with obesity were lower than control and they were negative correlated with weight, body mass index, C-reactive protein, uric acid, diastolic blood pressure, waist circumference, waist circumference/height ratio and white blood cell count. There were no significant differences in sRAGE levels between adolescents with or without metabolic syndrome, nor between boys and girls. Also, there were no significant differences in sRAGE levels between with or without insulin resistance.
conclusionssRAGE levels of the adolescents with obesity decreased. There was no difference in sRAGE levels between those with insulin resistance and metabolic syndrome compared to those without. Metabolic complications associated with obesity are important in terms of causing mortality and morbidity. Understanding the mechanisms could help to identify therapeutic strategies.
trial registrationNCT06771986| | https://www. CLINICALTRIALS: gov/ . Clinical Trial Registration Date: 2025/01/13.
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