Evidence map›Paper›PMID 40983874›Full record

ArticleMedical physics2025

Comprehensive characterization and validation of a fast-resolving (1000 Hz) plastic scintillator for ultra-high dose rate electron dosimetry.

Lixiang Guo, Banghao Zhou, Yi-Chun Tsai, Kai Jiang, Viktor Iakovenko, Ken Kang-Hsin Wang

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lixiang GuoBiomedical Imaging and Radiation Technology Laboratory (BIRTLab), Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Banghao ZhouBiomedical Imaging and Radiation Technology Laboratory (BIRTLab), Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Yi-Chun TsaiBiomedical Imaging and Radiation Technology Laboratory (BIRTLab), Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Kai JiangDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Viktor IakovenkoDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ken Kang-Hsin WangBiomedical Imaging and Radiation Technology Laboratory (BIRTLab), Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Funding

Cancer Prevention and Research Institute of Texas RR200042
6 · The paper itself

Abstract

backgroundThe normal tissue sparing effect of ultra-high dose rate irradiation (≥40 Gy/s, UHDR), as compared to conventional dose rate (CONV), has attracted significant research interest for FLASH radiotherapy (RT). Accurate, dose rate independent, fast-responding dosimeters capable of resolving the spatiotemporal characteristics of UHDR beams are urgently needed to facilitate FLASH research and support its clinical translation. Tissue-equivalent scintillators, with millimeter-level spatial resolution and millisecond-level temporal resolution, possess these required characteristics and show strong potential for use in UHDR dosimetry. PURPOSE: We investigated the performance of the HYPERSCINT RP-FLASH scintillator system at up to 1000 Hz sampling frequency (f

methodsThe scintillator was exposed to CONV and UHDR electron irradiation using a LINAC-based FLASH platform. Its spectral characteristics were delineated with a four-component calibration, followed by a signal-to-dose calibration using 18 MeV CONV electron beam. The dose linearity and dosimetric accuracy in response to CONV and UHDR irradiation at 1 and 1000 Hz f

resultsThe scintillator system at 1 Hz f

conclusionsWith routine dose calibration to account for radiation induced degradation, the fast-responding scintillator system can accurately provide millisecond-resolved inter-pulse measurements for electron beams at conventional and ultra-high dose rates, with minimal dependence on beam parameters. This suggests that the HYPERSCINT RP-FLASH scintillator system could serve as a detector of choice for electron FLASH research.

Indexed as

ElectronsPlasticsRadiation DosageRadiometryScintillation CountingTime FactorsPlasticsdosimetryFLASH radiotherapyscintillatorultrahigh dose rate

Identifiers

PMID40983874
PMCPMC12454735

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.