Evidence map›Paper›PMID 40983867›Full record

ArticleBiomacromolecules2025

Assessing the Mechanism of Action of Synthetic Nanoengineered Antimicrobial Polymers against the Bacterial Membrane of

Ramón Garcia Maset, Laia Pasquina-Lemonche, Alexia Hapeshi, Luke A Clifton, Jamie K Hobbs, Freya Harrison, Sébastien Perrier, Stephen C L Hall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ramón Garcia MasetWarwick Medical School, University of Warwick, Coventry CV4 7AL, U.K.
Laia Pasquina-LemoncheSchool of Biosciences, University of Sheffield, Sheffield S10 2TN, U.K.ORCID 0000-0002-8592-9542
Alexia HapeshiDepartment of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
Luke A CliftonISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Didcot OX11 0DE, U.K.ORCID 0000-0001-8754-362X
Jamie K HobbsSchool of Biosciences, University of Sheffield, Sheffield S10 2TN, U.K.ORCID 0000-0002-5872-1404
Freya HarrisonSchool of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K.ORCID 0000-0001-8449-5095
Sébastien PerrierWarwick Medical School, University of Warwick, Coventry CV4 7AL, U.K.ORCID 0000-0001-5055-9046
Stephen C L HallISIS Neutron and Muon Source, Rutherford Appleton Laboratory, Didcot OX11 0DE, U.K.ORCID 0000-0003-0753-5123

Funding

Wellcome Trust
6 · The paper itself

Abstract

The lack of appropriate antimicrobials to tackle multidrug-resistant Gram-negative bacteria poses an escalating threat to modern medicine. Addressing this urgent issue, we have recently developed synthetic nanoengineered antimicrobial polymers (SNAPs), inspired by the physicochemical properties of antimicrobial peptides. Our findings have demonstrated that SNAPs are potent antimicrobial agents characterized by low toxicity and cost-effective large-scale production. In this study, we elucidate the mechanism of action of two distinct SNAPs, which vary in length and charge distribution. Focusing on the Gram-negative pathogen

Indexed as

Anti-Bacterial AgentsAntimicrobial PeptidesCell MembranePolymersPseudomonas aeruginosaHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial PeptidesPolymers

Identifiers

PMID40983867
PMCPMC12522136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.