Evidence map›Paper›PMID 40983853›Full record

ArticleOphthalmology and therapy2025

Incidence and Predictors of Ocular Complications in Pediatric-Onset Uveitis: Data from the AIDA Network Uveitis Registry.

Carla Gaggiano, Alejandra De-la-Torre, Juanita Cardona-López, Silvana Guerriero, Gaafar Ragab, Maria Pia Paroli, Luciana Breda, Emanuela Del Giudice, Maria Tarsia, Jurgen Sota and 39 more

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Article in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

49 authors.

Carla GaggianoRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Policlinico "Le Scotte", Viale Bracci 16, 53100, Siena, Italy.
Alejandra De-la-TorreNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Juanita Cardona-LópezNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Silvana GuerrieroDepartment of Translational Medicine and Neurosciences (DiBraiN), Bari University, Bari, Italy.
Gaafar RagabInternal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Giza, Egypt.
Maria Pia ParoliUveitis Unit, Department of Sense Organs, Eye Clinic, Sapienza University of Rome, Rome, Italy.
Luciana BredaPediatric Rheumatology Unit, S.S. Annunziata Hospital, Chieti, Italy.
Emanuela Del GiudicePediatric and Neonatology Unit, Department of Maternal, Infantile, and Urological Sciences, Sapienza University of Rome, Polo Pontino, Latina, Italy.
Maria TarsiaClinical Pediatrics, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Siena, Italy.
Jurgen SotaRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Policlinico "Le Scotte", Viale Bracci 16, 53100, Siena, Italy.
Adele CivinoPaediatric Rheumatology and Immunology, Vito Fazzi Hospital, Lecce, Italy.
Marco CattaliniPediatric Clinic, University of Brescia and Spedali Civili di Brescia [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Brescia, Italy.
Antonio VitaleRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Policlinico "Le Scotte", Viale Bracci 16, 53100, Siena, Italy.
Stefano GentileschiRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Policlinico "Le Scotte", Viale Bracci 16, 53100, Siena, Italy.
Angela MauroPediatric Rheumatology Unit, Department of Childhood and Developmental Medicine, Fatebenefratelli-Sacco Hospital, Milan, Italy.
Sulaiman Al-MayoufDepartment of Pediatric Rheumatology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Soad HashadTripoli Children's Hospital, University of Tripoli, Tripoli, Libya.
Alex FonollosaDepartment of Ophthalmology, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country, Cruces Plaza, 48903, Barakaldo, Bizkaia, Spain.
Shereen Hassan Aboul NagaOphthalmology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Rana Hussein AminOphthalmology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Lampros FotisThird Department of Paediatrics, National and Kapodistrian University of Athens, General University Hospital "Attikon", Athens, Greece.
Maria Francesca GicchinoDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Valeria CaggianoRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Policlinico "Le Scotte", Viale Bracci 16, 53100, Siena, Italy.
Rosanna DammaccoDepartment of Translational Medicine and Neurosciences (DiBraiN), Bari University, Bari, Italy.
Maria Cristina MaggioUniversity Department PROMISE "G. D'Alessandro", University of Palermo, Palermo, Italy.
Daniela Rodríguez-CameloOphthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Maria Sole ChimentiRheumatology, Allergology and Clinical Immunology, Department of System Medicine, University of Rome "Tor Vergata", Rome, Italy.
Juliana Lopez-BonillaOphthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Ezgi Deniz BatuDivision of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, Turkey.
Seza OzenDivision of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, Turkey.
Francesca MinoiaPediatric Immuno-Rheumatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Abdurrahman TufanDivision of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, Turkey.
Mohamed Tharwat HegazyInternal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Giza, Egypt.
Kalpana BabuDepartment of Uvea and Ocular Inflammation, Prabha Eye Clinic and Research Centre and Vittala International Institute of Ophthalmology, Jayanagar, Bengaluru, Karnataka, India.
Jessica SbalchieroRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Policlinico "Le Scotte", Viale Bracci 16, 53100, Siena, Italy.
Abdelhafeez MoshrifRheumatology Department, Faculty of Medicine, Al-Azhar University, Asyût, Egypt.
Patrizia BaronePediatric Rheumatology Unit, Department of Integrated Maternal-Child and Reproduction Activity, AOU "Policlinico-San Marco", Catania, Italy.
Perla Ayumi Kawakami-CamposDepartment of Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Alessandro ConfortiOspedale San Paolo di Civitavecchia, U.O. Medicina Generale, ASL Roma 4, Civitavecchia, Rome, Italy.
Marcello GovoniUOC Reumatologia-Azienda Ospedaliero-Universitaria S. Anna-Ferrara (Loc. Cona), University of Ferrara, Ferrara, Italy.
Giovanni ContiPediatric Nephrology and Rheumatology Unit, Azienda Ospedaliera Universitaria (AOU) "G. Martino", University of Messina, Messina, Italy.
Maissa ThabetInternal Medicine Department, Farhat Hached University Hospital, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.
Francesco La TorreDepartment of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, Italy.
Ester CarreñoOphthalmology Unit, La Paz University Hospital, Madrid, Spain.
Vishali GuptaAdvanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Bruno FredianiRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Policlinico "Le Scotte", Viale Bracci 16, 53100, Siena, Italy.
Luca CantariniRheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Policlinico "Le Scotte", Viale Bracci 16, 53100, Siena, Italy. cantariniluca@hotmail.com.ORCID http://orcid.org/0000-0002-7352-1275
Claudia FabianiOphthalmology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena University Hospital [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Policlinico "Le Scotte", Viale Bracci 16, 53100, Siena, Italy. claudia.fabiani@aidanetwork.org.
on behalf the AIDA Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThis study aims to describe complications of pediatric-onset uveitis and their predictors among baseline and treatment-related factors.

methodsThis registry-based observational study included patients with noninfectious uveitis with disease onset < 18 years.

resultsA total of 309 patients were enrolled (535 eyes). Uveitis was anterior in 290 eyes (54.2%), panuveitis in 121 (22.6%), intermediate in 88 (16.4%), and posterior in 24 (4.5%). Over a median follow-up of 49.0 months (interquartile range [IQR] 101.0), 137 children (44.3%) developed ≥ 1 complication (14.4 per 100 patient-years). Idiopathic uveitis (p < 0.001), longer topical glucocorticoid (GC) monotherapy (p < 0.001) and longer delay of immunosuppressive therapy (IST) (p = 0.03) were associated with a higher frequency of complications. In multivariate analysis, anterior uveitis was protective against complications (odds ratio [OR] 0.10, 95% confidence interval [CI] - 4.1 to - 1.6, p < 0.001), whereas a chronic course of uveitis significantly increased the risk (OR 6.13, 95% CI 1.0-2.6, p < 0.001). Older age at onset was protective against cataract (OR 0.91, 95% CI - 0.2 to - 0.02, p = 0.020) and band keratopathy (OR 0.8, 95% CI - 0.4 to - 0.1, p = 0.003). Final best-corrected visual acuity (BCVA) (Snellen decimals) was inversely correlated with the duration of topical GC monotherapy (ρ = - 0.23; p = 0.001). In multivariate analysis, panuveitis was linked to a 0.142 decimal reduction (95% CI - 0.219 to - 0.066, p < 0.001), and cataract to a 0.295 reduction (95% CI - 0.372 to - 0.217, p < 0.001) in the final BCVA.

conclusionsChildren with chronic, idiopathic, early-onset, and non-anterior uveitis are at greatest risk for complications. Structured screening for these children, along with early initiation of systemic IST, is essential to prevent visual impairment.

Indexed as

ComplicationsIncidencePediatric-onset uveitisPredictorsVisual outcomes

Identifiers

PMID40983853
PMCPMC12534201

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