Evidence map›Paper›PMID 40983837›Full record

ArticlePharmaceutical research2025

Glutathione-Responsive Supramolecular Micelles Based on β-Cyclodextrin Construction: Combining Photodynamic Therapy and Chemotherapy for Cancer Treatment.

Chao Zhou, Shuqing Zhang, Yamin Li, Yi Yao, Tian Si, Bo Yang

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Article in Pharmaceutical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chao Zhou *Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Shuqing Zhang *Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Yamin Li *Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Yi Yao *Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Tian SiFaculty of Chemical Engineering, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China. 233361680@qq.com.
Bo YangFaculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China. yangbo6910@sina.com.

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 21642001the National Natural Science Foundation of China (NNSFC) 21961017
6 · The paper itself

Abstract

purposeAnticancer drugs often suffer from poor water solubility, low utilization rates, and high side effects, which significantly impact cancer treatment. This study aims to design and develop a multi-therapy intelligent drug delivery system that can address these issues and improve the therapeutic efficacy of cancer treatment by combining chemotherapy and photodynamic therapy.

methodsAn amphiphilic supramolecular, TPPC6-SS-CD, based on β-cyclodextrin and porphyrin derivatives, was synthesized. The compound self-assembles into micelles in aqueous solution, demonstrating glutathione-responsive properties.

resultsThe micelles were successfully cleaved by glutathione, enabling the release of etoposide and porphyrin. This release resulted in combined chemotherapy and photodynamic therapy, inducing tumor cell death. Under 425 nm irradiation, the micelles loaded with etoposide showed better tumor cell growth inhibition compared to the free etoposide and porphyrin.

conclusionThis study presents a new type of supramolecular nanocarriers designed for the combined delivery of chemotherapy and photodynamic therapy. The findings demonstrate the potential of this system for tumor treatment, offering valuable insights for the development of drug delivery vectors in biological, chemical, and photodynamic industries.

Indexed as

Antineoplastic Agentsbeta-CyclodextrinsEtoposideGlutathioneNeoplasmsPhotochemotherapyCell Line, TumorCell SurvivalDrug CarriersDrug Delivery SystemsDrug LiberationHumansMicellesPhotosensitizing AgentsPorphyrinsAntineoplastic Agentsbeta-CyclodextrinsbetadexDrug CarriersEtoposideGlutathioneMicellesPhotosensitizing AgentsPorphyrinsChemotherapyCyclodextrinMicellePhotodynamic therapyPorphyrin

Identifiers

PMID40983837

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.