Evidence map›Paper›PMID 40983781›Full record

ArticleEuropean journal of applied physiology2026

The impact of posture changes on critical closing pressure and resistance-area product regulation in healthy subjects.

X Zhong, R H Clough, R B Panerai, J S Minhas

Abstract read
In one paragraph

Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

X ZhongCerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
R H CloughCerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
R B Panerai *Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
J S Minhas *Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. jm591@le.ac.uk.ORCID http://orcid.org/0000-0002-0576-9105

Funding

Stroke Association SA SCLM23\100003UK Research and Innovation MR/Y016807/1
6 · The paper itself

Abstract

introductionCerebral blood flow (CBF) is affected by posture changes, but there is a paucity of research examining the effect of posture on dynamic cerebral autoregulation (dCA). The step responses of critical closing pressure (CrCP) and resistance area product (RAP) obtained from the cerebral blood velocity (CBv) signal can reflect the changes in dCA, enabling exploration of dCA changes in supine, sitting and upright postures.

methodsIn 22 participants (11 males, aged 30.2 ± 14.3 years), two recordings were made for each posture, corresponding to supine, sitting, and standing. Blood pressure (BP, Finometer), MCAv and PCAv (transcranial Doppler ultrasound), end-tidal carbon dioxide (EtCO

resultsMoving from supine to sitting, and then standing, led to reductions in mean MCAv (p < 0.001), PCAv (p = 0.037), BP (p < 0.001) and EtCO

conclusionPosture changes can significantly affect the step responses of MCAv, CrCP, and RAP. The interaction between posture and EtCO

Indexed as

Cerebrovascular CirculationPostureVascular ResistanceAdultBlood Flow VelocityBlood PressureFemaleHeart RateHomeostasisHumansMaleCerebral blood flowPostureVasomotor reactivity

Identifiers

PMID40983781
PMCPMC12948903

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.