Evidence map›Paper›PMID 40983732›Full record

ArticleThe Journal of antibiotics2025

Linfuranone F, a PPARγ-agonistic furanone-containing polyketide, from a rare actinomycete Sphaerimonospora sp.

Desy Wulan Triningsih, Nobuyasu Matsuura, Hisayuki Komaki, Enjuro Harunari, Yasuhiro Igarashi

Abstract read
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Article in The Journal of antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Desy Wulan TriningsihBiotechnology Research Center and Department of Biotechnology, Toyama Prefectural University 5180 Kurokawa, Imizu, Toyama, Japan.ORCID 0000-0002-0934-8543
Nobuyasu MatsuuraOkayama University of Science, Okayama, Japan.
Hisayuki KomakiBiological Resource Center, National Institute of Technology and Evaluation (NBRC), 2-5-8 Kazusakamatari, Chiba, Japan.
Enjuro HarunariBiotechnology Research Center and Department of Biotechnology, Toyama Prefectural University 5180 Kurokawa, Imizu, Toyama, Japan.ORCID 0000-0001-8726-0865
Yasuhiro IgarashiBiotechnology Research Center and Department of Biotechnology, Toyama Prefectural University 5180 Kurokawa, Imizu, Toyama, Japan. yas@pu-toyama.ac.jp.ORCID 0000-0001-5114-1389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Linfuranone F (1), a new furanone-containing polyketide, was isolated from the culture extract of an actinomycete of the genus Sphaerimonospora along with three known linfuranones B (2), C (3), and D (4). Compound 1 was established as a 6,7-dehydrated congener of 3 by comparing their spectroscopic data and considering their biosynthetic relatedness. All compounds displayed agonistic activity against PPARγ in a reporter gene assay and 1 showed the highest activity.

Indexed as

ActinobacteriaFuransPolyketidesPPAR gammaHumansMagnetic Resonance SpectroscopyMolecular StructureFuransPolyketidesPPAR gamma

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.