ArticleBiomechanics and modeling in mechanobiology2025
Biomechanical stress profiling in coronary arteries via two-phase blood FSI.
Article in Biomechanics and modeling in mechanobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Haemodynamic and biomechanical biomarker analysis of carotid fibromuscular dysplasia via fluid-structure interaction.Biomechanics and modeling in mechanobiology · 2026Article
- Developing a non-invasive diagnostic framework for the fractional flow reserve quantification in left coronary arteries: validation with patient cases.Frontiers in physiology · 2026Article
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4 authors.
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Abstract
This study focuses on the biomechanical stress determination of the left circumflex (LCx) coronary artery reconstructed based on in vivo angiography images via the development of a comprehensive biomechanical model incorporating a two-phase two-way coupled three-dimensional fluid-structure interaction (FSI). The blood flow is modelled as a two-phase pulsatile fluid, with 45% red blood cells and 55% plasma, and the artery wall is modelled as a soft viscohyperelastic material that is able to dynamically react to the blood-induced pressure. The flow characteristics, such as pressure, velocity, phase distribution, near-wall haemodynamic parameters, and flow-induced indices, are determined. The von Mises stress (VMS) and the deformation field of the arterial wall are also obtained. Comparing results based on the two-phase FSI model and those of a single-phase FSI show that taking into account the red blood cells alters the stresses, providing a better understanding of potential cardiovascular events. In all the cases investigated in this study, the wall shear stress (WSS) levels predicted by the two-phase FSI model are consistently lower than those obtained from the single-phase simulations. For example, at the location of maximum WSS during peak systole, the single-phase simulation employing the Quemada viscosity model predicts 143.43 Pa, whereas the single-phase simulation based on the power-law model predicts 39.85 Pa. In contrast, the two-phase model yields a substantially lower value of 24.79 Pa.
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