Evidence map›Paper›PMID 40983689›Full record

ArticleEye (London, England)2025

Initial circumpapillary retinal nerve fibre layer rates of change predict glaucomatous progression.

Vincent Q Pham, Takashi Nishida, Sasan Moghimi, Naimul Alam, Christopher A Girkin, Massimo A Fazio, Jeffrey M Liebmann, Linda M Zangwill, Robert N Weinreb

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vincent Q PhamHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1765-1921
Takashi NishidaHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8312-6623
Sasan MoghimiHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Naimul AlamHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Christopher A GirkinDepartment of Ophthalmology and Visual Science, Heersink School of Medicine, University of Alabama-Birmingham, Birmingham, AL, USA.
Massimo A FazioDepartment of Ophthalmology and Visual Science, Heersink School of Medicine, University of Alabama-Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-7489-089X
Jeffrey M LiebmannBernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, NY, USA.
Linda M ZangwillHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.
Robert N WeinrebHamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA. rweinreb@health.ucsd.edu.ORCID http://orcid.org/0000-0001-9553-3202

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Radha Ayyagari · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
Age-related changes in optic nerve head structure and biomechanicsR01EY018926 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DOWNS, J CRAWFORD, GIRKIN, CHRISTOPHER ANTHONY · 2008 to 2015
$2.6M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
Research to Prevent Blindness (RPB) Unrestricted GrantTobacco-Related Disease Research Program (TRDRP) T34IR8095U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30EY022589U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EY018926U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EY019869U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EY026574U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EY027510U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01EY029058
6 · The paper itself

Abstract

objectivesTo investigate whether the rate of circumpapillary retinal nerve fibre layer (cpRNFL) change during initial follow-up can predict event progression detected by guided progression analysis (GPA) over an extended follow-up.

methodsPrimary open-angle glaucoma (POAG) and glaucoma suspect patients with a minimum of seven optical coherence tomography (OCT) scans were analysed. The cpRNFL slopes were calculated for an initial follow-up of 2, 3, 4, and 5 visits (6 months apart for each visit) using a linear mixed-effects model. After the initial follow-up, the event date was then marked as the date of the first OCT test that indicated likely progression using GPA software. The cumulative risk of progression in slow (>-1.0 µm/year) vs moderate-and-fast (≤-1.0 µm/year) initial OCT slopes was compared using Kaplan-Meier survival analysis and log-rank test for the optimal scenarios.

resultsThe study included 472 eyes (340 POAG and 132 glaucoma suspects) from 307 patients. The optimal scenario for predicting GPA progression over the ensuing 3 years included the initial 4 OCT sessions (the adjusted-HR = 1.76 (95% CI: 1.37-2.26) per initial 1 μm/faster; P < 0.001. For predicting progression over the next 5 years, the optimal scenario included the initial 5 OCT sessions that occurred for the first 2 years. The adjusted-HR was 1.65 (95% CI: 1.16-2.33) per initial 1 μm/faster; P = 0.005.

conclusionsThe rate of initial cpRNFL change observed within half the monitoring period may effectively predict the subsequent structural progression and can be used by clinicians to predict the course of glaucoma when monitoring patients.

Indexed as

Glaucoma, Open-AngleNerve FibersOptic DiskRetinal Ganglion CellsAgedDisease ProgressionFemaleFollow-Up StudiesHumansIntraocular PressureMaleMiddle AgedRetrospective StudiesTomography, Optical CoherenceVisual Fields

Identifiers

PMID40983689
PMCPMC12583829

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.