Evidence map›Paper›PMID 40983688›Full record

ArticlePsychopharmacology2026

Reducing effects of isoliquiritigenin, a naturally occurring GABA

Paola Maccioni, Laura Regonini Somenzi, Mauro A M Carai, Federico Corelli, Gian Luigi Gessa, Giancarlo Colombo

Abstract read
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In one paragraph

Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paola MaccioniNeuroscience Institute, Section of Cagliari, National Research Council of Italy, S.S. 55, km. 4,500, I-09042, Monserrato, CA, Italy.
Laura Regonini SomenziNeuroscience Institute, Section of Cagliari, National Research Council of Italy, S.S. 55, km. 4,500, I-09042, Monserrato, CA, Italy.
Mauro A M CaraiCagliari Pharmacological Research, Cagliari, CA, Italy.
Federico CorelliDepartment of Biotechnology, Chemistry, and Pharmacy, University of Siena, Siena, SI, Italy.
Gian Luigi GessaNeuroscience Institute, Section of Cagliari, National Research Council of Italy, S.S. 55, km. 4,500, I-09042, Monserrato, CA, Italy.
Giancarlo ColomboNeuroscience Institute, Section of Cagliari, National Research Council of Italy, S.S. 55, km. 4,500, I-09042, Monserrato, CA, Italy. colomb@unica.it.ORCID http://orcid.org/0000-0002-0194-8149

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RATIONALE AND

objectivesGlycyrrhiza glabra L. (Fabaceae; licorice) is a widely used medicinal herb known to exert protective effects against multiple neurological diseases. The flavonoid, isoliquiritigenin (ISL), is a main constituent of roots of Glycyrrhiza glabra. ISL has been reported to behave as a GABA METHODS AND

resultsThe collected results indicated that acute treatment with ISL (5-20 mg/kg, i.p.; 50-200 mg/kg, i.g.) decreased operant oral alcohol self-administration under both fixed and progressive ratio schedules of reinforcement and suppressed cue-induced reinstatement of alcohol seeking. ISL effect on alcohol self-administration was partially blocked by pretreatment with the GABA

conclusionsThese results confirm the ability of ISL to behave in vivo as a GABA

Indexed as

Alcohol DrinkingChalconesEthanolGABA-B Receptor AgonistsMotivationAnimalsBaclofenBehavior, AnimalCyclopentanesDose-Response Relationship, DrugFemaleMotor ActivityRatsReceptors, GABA-BSelf AdministrationBaclofenChalconesCyclopentanesEthanolGABA-B Receptor AgonistsisoliquiritigeninReceptors, GABA-BAlcohol-preferring ratsAlcohol self-administrationBaclofenGABAB receptorGlycyrrhiza glabra L.IsoliquiritigeninLicoriceReinstatement of alcohol seeking

Identifiers

PMID40983688
PMCPMC13242392

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.