Evidence map›Paper›PMID 40983503›Full record

ArticleGut2026

Gastrin-dependent expansion of Cck2r

Biyun Zheng, Hiroki Kobayashi, Ruhong Tu, Kexuan Huang, Xiaofei Zhi, Guodong Lian, Feijing Wu, Jin Qian, Yosuke Ochiai, Quin T Waterbury and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Biyun ZhengDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Hiroki KobayashiDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.ORCID http://orcid.org/0000-0002-1717-4870
Ruhong TuDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Kexuan HuangDepartment of Biological Sciences, Columbia University, New York, New York, USA.
Xiaofei ZhiDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Guodong LianDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Feijing WuDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Jin QianDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Yosuke OchiaiDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Quin T WaterburyDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Ermanno MalagolaDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Jiaoqian LuDepartment of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Masahiro HataDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Yi ZengDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Hualong ZhengDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Puran ZhangDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Shuang LiDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Leah ZamechekDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Xiaozhong WangDepartment of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Fenglin ChenDepartment of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Timothy C WangDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA tcw21@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-7940-8310

Funding

The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2M
Gastroesophageal junction stem cells as the origin of Barretts esophagus and cancerR01CA272901 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN, WANG, TIMOTHY CRAGIN · 2022 to 2025
$4.9M
Gastrin Regulation of Gastric Antral Stem and Corpus Progenitor CellsR01DK128195 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, TIMOTHY CRAGIN · 2021 to 2024
$2.0M
NCI NIH HHS R01 CA272901NCI NIH HHS R35 CA210088NIDDK NIH HHS R01 DK128195
6 · The paper itself

Abstract

backgroundThe cholecystokinin-2/gastrin receptor (Cck2r) is expressed in corpus isthmus progenitor, enterochromaffin-like and parietal cells, regulating acid secretion and cell turnover. However, the role of gastrin on Cck2r progenitors during mucosal regeneration remains unexplored.

objectiveTo study the role of gastrin-Cck2r axis and corpus progenitors during gastric injury and regeneration.

designWe generated Cck2r-CreERT2; Gastrin-DTR-p2A-TdTomato; Rosa26-ZsGreen mice to trace corpus Cck2r

resultsHypergastrinaemia significantly expanded Cck2r

conclusionsWe report a novel role for G-cell-derived gastrin in ulcer healing. Hypogastrinaemia is a risk factor for poor ulcer healing, corpus atrophy and potentially cancer, while physiological gastrin responses are protective. PPI-induced hypergastrinaemia plays a key role in ulcer healing, and gastrin signalling may prevent gastric preneoplasia.

Indexed as

Gastric MucosaGastrinsReceptor, Cholecystokinin BStem CellsStomach UlcerWound HealingAnimalsDisease Models, AnimalHelicobacter InfectionsHelicobacter pyloriMiceProton Pump InhibitorsRegenerationGastrinsProton Pump InhibitorsReceptor, Cholecystokinin BDYSPLASIAGASTRIC AND DUODENAL ULCERSGASTRINHELICOBACTER PYLORI - GASTRITISMUCOSAL REPAIR

Identifiers

PMID40983503
PMCPMC13056005

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.