ArticleAmerican journal of physiology. Heart and circulatory physiology2025
Multiomic and electrophysiologic analyses reveal that an inherited MRC2 variant causes fibroblast dysfunction and increased atrial fibrillation susceptibility.
Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Kevin S HoDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0003-0015-5339
Joshua A KeefeDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0002-6209-6488
Shuai ZhaoDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas, United States.ORCID 0009-0007-0006-8987
Mohit M HulsurkarDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0003-0595-6661
Sung Yun JungDepartment of Biochemistry, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0003-1521-7977
Md Abul Hassan SameeDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0002-7472-1156
Xander H T WehrensDepartment of Integrative Physiology, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0001-5044-672X
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Ryanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5M
Junctophilin-2 cleavage in ischemic heart diseaseR01HL153350 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2021 to 2024
$2.3M
Role of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1M
Mechanisms underlying atrial fibrillation associated with chronic kidney diseaseR01HL147108 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA, WEHRENS, XANDER H.T. · 2019 to 2022
$2.0M
Role of inflammation in postoperative atrial fibrillationR01HL180477 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2025 to 2026
$1.5M
Cardiomyocyte-fibroblast signaling in atrial fibrillationR01HL174510 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2025 to 2026
$1.3M
Supporting Cancer Research as a Core-based Scientist by Providing Comprehensive Genetically Engineered Rodent Model ServicesR50CA283804 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Lan Liao · 2024 to 2026
$430k
Targeting the Calcitonin-BMP1 Pathway in Atrial Cardiofibroblasts to Ameliorate Atrial FibrillationF30HL167574 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HO, KEVIN SON · 2023 to 2025
$150k
Macrophage-mediated interleukin-6 signaling drives ryanodine receptor 2 calcium leak in postoperative atrial fibrillationF30HL172431 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KEEFE, JOSHUA ANTHONY · 2024 to 2025
$99k
HHS | National Institutes of Health (NIH) F30HL167574HHS | National Institutes of Health (NIH) F30HL172431HHS | National Institutes of Health (NIH) R01HL089598HHS | National Institutes of Health (NIH) R01HL147108HHS | National Institutes of Health (NIH) R01-HL153350HHS | National Institutes of Health (NIH) R01-HL160992HHS | NIH | National Cancer Institute (NCI) P30CA125123HHS | NIH | National Cancer Institute (NCI) R50CA283804NCI NIH HHS P30 CA125123NCI NIH HHS R50 CA283804NHLBI NIH HHS F30 HL167574NHLBI NIH HHS F30 HL172431NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL147108NHLBI NIH HHS R01 HL153350NHLBI NIH HHS R01 HL160992NHLBI NIH HHS R01 HL174510NHLBI NIH HHS R01 HL180477
6 · The paper itself
Abstract
A recent study identified a rare variant in the mannose receptor C type 2 (
Indexed as
Atrial FibrillationFibroblastsReceptors, Cell SurfaceAction PotentialsAnimalsCells, CulturedConnective Tissue Growth FactorDisease Models, AnimalFibrosisGenetic Predisposition to DiseaseHeart AtriaMaleMiceMice, Inbred C57BLPhenotypeProteomicsCCN2 protein, mouseConnective Tissue Growth FactorReceptors, Cell Surfaceatrial fibrillationEndo180fibrosismannose receptor C type 2MRC2
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Multiomic and electrophysiologic analyses reveal that an inherited MRC2 variant causes fibroblast dysfunction and increased atrial fibrillation susceptibility. · full record | OpenQuestion