Microbe-responsive human γδ T cells: the peculiar case of Staphylococcus aureus.

Matthias Eberl, Manuel Mata Forsberg, James E McLaren, Eva Sverremark-Ekström

Abstract readReview

In one paragraph

Review in Immunology and cell biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed, 1 pooled it

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

Research progress on T-cell responses inFrontiers in microbiology · 2026
Pooled it

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthias EberlDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-9390-5348

Manuel Mata ForsbergDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

James E McLarenDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-7021-5934

Eva Sverremark-EkströmDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-6271-8681

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vγ9/Vδ2 T cells represent the largest γδ T-cell population in human blood and possess a unique responsiveness towards microbial organisms by sensing the metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP) in the context of the butyrophilin family members BTN2A1 and BTN3A1. Curiously, the bacterium Staphylococcus aureus does not produce HMB-PP but appears to be capable of inducing activation, cytokine expression and proliferation of Vγ9/Vδ2 T cells regardless, through a largely unknown mechanism. We here provide a comprehensive review of the existing literature around Vγ9/Vδ2 T-cell responses to S. aureus and discuss potential pathways, ligands and biological functions.

Indexed as

Receptors, Antigen, T-Cell, gamma-deltaStaphylococcal InfectionsStaphylococcus aureusT-LymphocytesT-Lymphocyte SubsetsAntigens, CDButyrophilinsCytokinesHumansLymphocyte ActivationAntigens, CDBTN3A1 protein, humanButyrophilinsCytokinesReceptors, Antigen, T-Cell, gamma-deltabacteriaimmunityinfectionStaphylococcus aureussuperantigensγδ T cells

Identifiers

PMID40983319

DOI10.1111/imcb.70060

PMCPMC12593184

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.