ArticleThe Journal of nutrition2025
Associations of Serum n-6 Polyunsaturated Fatty Acid Concentrations with Heart Rate-Corrected QT and JT Intervals in Middle-Aged Males.
Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAlthough n-6 (ω-6) polyunsaturated fatty acids (PUFAs), particularly the main n-6 PUFA linoleic acid (LA), have been shown to be inversely related to cardiovascular disease (CVD) risk, their associations with ventricular repolarization, a marker of ventricular arrhythmias, remain unclear.
objectivesThis study examined the relationships between serum n-6 PUFA concentrations and heart rate-corrected QT (QTc) and JT (JTc) intervals.
methodsThis cross-sectional study included 1420 Finnish males (aged 42-60 y) free of CVD from the Kuopio Ischaemic Heart Disease Risk Factor Study. Fasting serum n-6 PUFA concentrations were determined by gas chromatography, and electrocardiographic intervals were automatically derived. QTc and JTc intervals were calculated using Bazett's formula. Associations were analyzed using multivariable-adjusted analysis of covariance.
resultsHigher serum total n-6 PUFA concentrations were associated with shorter QTc and JTc intervals [QTc, extreme-quartile difference: -3.36 ms; 95% confidence interval (CI): -6.69, -0.41; P-trend = 0.02; JTc, extreme-quartile difference: -3.38 ms; 95% CI: -6.79, -0.27; P-trend = 0.03]. Similar inverse associations were found for serum LA (QTc: -4.64 ms; 95% CI: -8.00, -1.27; P-trend = 0.009; JTc: -3.99 ms; 95% CI: -7.44, -0.54; P-trend = 0.02). The other n-6 PUFAs-γ-linolenic acid, dihomo-γ-linolenic acid, and arachidonic acid-showed no significant associations.
conclusionsHigher serum total n-6 PUFA and LA concentrations are associated with shorter QTc and JTc intervals, suggesting a potential protective effect on ventricular arrhythmias.
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