ArticleNeurology(R) neuroimmunology & neuroinflammation2025
Amaurosis Fugax Dolorosa: A Prodromal Syndrome in Optic Neuritis Associated With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
Article in Neurology(R) neuroimmunology & neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Amaurosis Fugax Dolorosa: A Prodromal Syndrome in Optic Neuritis Associated With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAmaurosis fugax (AF) is typically vascular but can rarely be associated with optic neuritis (ON). We describe AF preceding myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) ON.
methodsWe retrospectively reviewed our MOGAD cohort (July 2024-April 2024). Inclusion criteria were (1) AF-defined as transient visual loss <24 hours without retinal ischemic lesions-before first ON and (2) fulfilled international MOGAD 2023 diagnostic criteria. Demographics, symptoms/signs, MRI, and optical coherence tomography (OCT) data were collected. Descriptive statistics summarized the findings.
resultsIn total, 8 of 350 (2.3%) MOGAD patients with ON experienced AF. Most patients (7/8, 87.5%) were women, and all reported periocular pain. Transient visual episodes were typically brief (median, 15 minutes; range, 1-300 minutes) and usually less than 1 hour (6/8, 75.0%). Amaurosis fugax affected the right (n = 4), left (n = 3), or both (n = 1) eyes. Within 1 week, 7 developed ON. MRI showed optic nerve enhancement in involved eye in 8 of 8 (100%). OCT completed in 1 patient at the time of AF showed increased peripapillary retinal nerve fiber layer thickness. No alternative diagnoses emerged during follow-up. DISCUSSION: Painful AF is a previously unrecognized and specific prodrome of MOGAD-associated ON; identifying this rare presentation may enable earlier diagnosis and treatment.
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