Evidence map›Paper›PMID 40982687›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

In vitro maturation of fully active [FeFe]-hydrogenase in a defined system including the iron carrier NfuA.

Alexander Marlott, Adrien Pagnier, Eric M Shepard, Batuhan Balci, Abraham Teye, Douglas M Warui, Hao Yang, Alex Drena, Squire J Booker, Brian M Hoffman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexander MarlottDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717.
Adrien PagnierDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717.
Eric M ShepardDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717.
Batuhan BalciDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717.
Abraham TeyeDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717.
Douglas M WaruiDepartment of Chemistry and Howard Hughes Medical Institute, The Pennsylvania State University, University Park, PA 16802.
Hao YangDeparment of Chemistry, Northwestern University, Evanston, Il. 60208.ORCID 0000-0001-7229-0957
Alex DrenaDeparment of Chemistry, Northwestern University, Evanston, Il. 60208.
Squire J BookerDepartment of Chemistry and Howard Hughes Medical Institute, The Pennsylvania State University, University Park, PA 16802.ORCID 0000-0002-7211-5937
Brian M HoffmanDeparment of Chemistry, Northwestern University, Evanston, Il. 60208.ORCID 0000-0002-3100-0746
William E BroderickDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717.ORCID 0000-0001-5782-7322
Joan B BroderickDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717.ORCID 0000-0001-7057-9124

Funding

HHS | National Institutes of Health (NIH) GM111097HHS | National Institutes of Health (NIH) GM122595National Science Foundation (NSF) MCB 1716686U.S. Department of Energy (DOE) DE-SC0005404
6 · The paper itself

Abstract

The [FeFe]-hydrogenase employs an active-site 6Fe H-cluster to catalyze the reversible reduction of protons to H

Indexed as

Escherichia coliEscherichia coli ProteinsHydrogenaseIron-Sulfur ProteinsChlamydomonas reinhardtiiHydrogenIronEscherichia coli ProteinsHydrogenHydrogenaseIroniron hydrogenaseIron-Sulfur Proteinshydrogenaseiron carrier proteiniron-sulfur clustermaturationradical SAM

Identifiers

PMID40982687
PMCPMC12501116

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.