ArticleProceedings of the National Academy of Sciences of the United States of America2025
Childhood allostatic load predicts cardiometabolic health in adulthood.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Allostatic load (AL) measures multisystem physiological functioning to reflect the cumulative burden of chronic stress. Incurring AL during sensitive developmental periods such as childhood may affect health outcomes later in life, but longitudinal measures to test these life course effects are lacking. This study tested associations between childhood AL and adult cardiometabolic health in a large sample of youth repeatedly measured across ages 9 to 16, and their adult cardiometabolic health at age 30. AL scores were calculated at each age by summing across sex- and age-standardized values for biomarkers representing immune (C-Reactive Protein, Epstein-Barr Virus antibodies), neuroendocrine (cortisol, DHEA-s), and cardiometabolic indicators (body mass index; BMI). Adult cardiometabolic health was measured using a composite sum score of sex-standardized systolic and diastolic blood pressure, BMI, and waist-to-hip ratio. Multiple approaches aggregating repeated AL scores were tested, including mean, maximum, oldest available AL score across childhood, and a version omitting BMI from the index. Childhood AL was significantly associated with adult cardiometabolic health (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.