Evidence map›Paper›PMID 40982683›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Prospects for detecting signs of life on exoplanets in the JWST era.

Sara Seager, Luis Welbanks, Lucas Ellerbroek, William Bains, Janusz J Petkowski

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Characterization of exoplanets in the James Webb Space Telescope era.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Multi-technique characterization of iron reduction by an AntarcticApplied and environmental microbiology · 2025
    Article
  4. The diversity of exoplanetary environments and the search for signs of life beyond Earth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sara SeagerDepartment of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-6892-6948
Luis WelbanksSchool of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287.ORCID 0000-0003-0156-4564
Lucas EllerbroekDepartment of Astrophysics/Institute for Mathematics, Astrophysics and Particle Physics, Radboud University, Nijmegen 6500 GL, The Netherlands.ORCID 0000-0003-0531-5952
William BainsSchool of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA, United Kingdom.
Janusz J PetkowskiJJ Scientific, Warsaw, Mazowieckie 02-792, Poland.ORCID 0000-0002-1921-4848

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The search for signs of life in the Universe has entered a new phase with the advent of the James Webb Space Telescope (JWST). Detecting biosignature gases via exoplanet atmosphere transmission spectroscopy is in principle within JWST's reach. We reflect on JWST's early results in the context of the potential search for biological activity on exoplanets. The results confront us with a complex reality. Established inverse methods to interpret observed spectra-already known to be highly averaged representations of intricate three dimensional (3D) atmospheric processes-can lead to disparate interpretations even with JWST's quality of data. Characterizing rocky or sub-Neptune-size exoplanets with JWST is an intricate task, and moves us away from the notion of finding a definitive "silver bullet" biosignature gas. Indeed, JWST results necessitate us to allow "parallel interpretations" that will perhaps not be resolved until the next generation of observatories. Nonetheless, with a handful of habitable-zone planet atmospheres accessible given the anticipated noise floor, JWST may continue to contribute to this journey by designating a planet as biosignature gas candidate. To do this we will need to sufficiently refine our inverse methods and physical models for confidently quantifying specific gas abundances and constraining the atmosphere context. Looking ahead, future telescopes and innovative observational strategies will be essential for the reliable detection of biosignature gases.

Indexed as

astrobiologybiosignaturesexoplanetsplanetary atmospheres

Identifiers

PMID40982683
PMCPMC12501172

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.