ArticleProceedings of the National Academy of Sciences of the United States of America2025
Disentangling metabolic and neurovascular timescales supporting cognitive processes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Ketamine alters the aperiodic EEG exponent in major depression: implications for cortical E/I balance and treatment prediction.Therapeutic advances in psychopharmacology · 2026Article
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Authors and funding
7 authors.
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Abstract
The balance between neural excitation and inhibition (EIB), governed by glutamatergic and GABAergic neurotransmission, is an essential mechanism supporting cognitive processes. Yet, little is understood about how EIB shifts with engaging cognitive load and its impact on functional connectivity dynamics. Here, we combined time-resolved functional magnetic resonance spectroscopy and magnetic resonance imaging to investigate temporal profiles of the reciprocal modulation between EIB and functional network dynamics during working memory tasks in healthy subjects. We quantified EIB kinetics by measuring excitatory (Glx) and inhibitory (GABA+) levels and assessed their temporal coupling with dynamic functional connectivity states, revealing a dependence that scales with cognitive load. Notably, we found that as cognitive challenges intensify, brain networks transition toward more specialized and enduring connectivity configurations, accompanied by imbalances that favor excitation, changes that may impact cognitive adaptability. Fluctuations in EIB and functional connectivity occurred on comparable timescales and were both associated with individual differences in cognitive performance. Importantly, this experimental approach demonstrates a close synergy between EIB kinetics, brain network dynamics, and cognitive performance, defining the groundwork for exploring healthy and aberrant cognitive states.
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