ArticleAnalytical chemistry2025
Not Just Better Resolution: A Detailed Study of the Signal Distribution in Mid-Infrared Optical Photothermal Imaging.
Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Demystifying Experimental Parameters in Optical Photothermal Imaging in Aqueous Media.ACS omega · 2026Article
- Intrinsic OPTIR imaging and spectroscopy enable label-free monitoring of viral infection in living cells.Analytical and bioanalytical chemistry · 2026Article
- Leveraging image processing techniques to visualize sub-cellular domains in optical photothermal infrared imaging.The Analyst · 2026Article
- Picogram-Level Nanoplastic Analysis with Nanoelectromechanical System Fourier Transform Infrared Spectroscopy: NEMS-FTIR.ACS nano · 2026Article
- Investigating Spectral Biomarker Candidates for Migratory Potential in Cancer Cells Using Micro-FTIR and O‑PTIR Spectroscopy.ACS measurement science au · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
The spatial resolution of an imaging system is generally evaluated by analysis of the point spread function (PSF), that is, the system response to a point source in the object plane. The PSF, albeit a fundamental concept in light microscopy, has been sparsely studied in optical photothermal infrared (O-PTIR) imaging. Although there is only a minor difference between the photothermal and optical intensity distributions in the radial direction, the axial photothermal signal is markedly different from the imaging response of conventional light microscopes. Previous studies of particles beyond the visible diffraction limit have shown that the O-PTIR signal has two lobes and strongly varies with the offset between the foci of the pump and the probe laser. We will therefore present theoretical and experimental data to investigate the radial and axial intensity distributions of a commercial Raman microscope and a custom O-PTIR transmission instrument, with particular emphasis on the axial PSF of the O-PTIR system. Our data suggest that the two-lobed signal shape is also present in objects on the order of the probe beam wavelength.
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Registered trials
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